Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

In eukaryotic cells, macromolecular homeostasis requires selective degradation of damaged
units by the ubiquitin-proteasome system (UPS) and autophagy. Thus, dysfunctional …

Cell death was once believed to be the result of one of two distinct processes, apoptosis
(also known as programmed cell death) or necrosis (uncontrolled cell death); in recent …

The antimalarial drug artemisinin and its derivatives have been explored as potential
anticancer agents, but their underlying mechanisms are controversial. In this study, we found …

Methamphetamine (METH) is an illicit psychostimulant that is abused throughout the world.
METH addiction is also a major public health concern and the abuse of large doses of the …

Lysosomes are single membrane-bound organelles containing acid hydrolases responsible
for the degradation of cellular cargo and maintenance of cellular homeostasis. Lysosomes …

Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins,
damaged organelles and misfolded proteins are degraded and recycled for the …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Diabetic retinopathy (DR) is one of the leading causes of blindness in the world, and timely
prevention and treatment are very important. Previously, we found that a neurodegenerative …

DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …