Base editing—the introduction of single-nucleotide variants (SNVs) into DNA or RNA in
living cells—is one of the most recent advances in the field of genome editing. As around …

Abstract N 6-methyl-2′-deoxyadenosine (6mA or m6dA) has been reported in the DNA of
prokaryotes and eukaryotes ranging from unicellular protozoa and algae to multicellular …

Cytosine base editors (CBEs) enable targeted C• G-to-T• A conversions in genomic DNA.
Recent studies report that BE3, the original CBE, induces a low frequency of genome-wide …

The spontaneous deamination of cytosine is a major source of transitions from C• G to T• A
base pairs, which account for half of known pathogenic point mutations in humans. The …

The genome is constantly attacked by genotoxic insults. DNA damage has long been
established as a cause of cancer development through its mutagenic consequences …

Accurate estimates of virus mutation rates are important to understand the evolution of the
viruses and to combat them. However, methods of estimation are varied and often complex …

Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of
genetic and environmental factors. Although it is one of the most common cancers …

Cas12a (Cpf1) is an RNA-guided endonuclease in the bacterial type VA CRISPR-Cas anti-
phage immune system that can be repurposed for genome editing. Cas12a can bind and cut …

Epigenetics is a change in gene expression that is heritable without a change in DNA
sequence itself. This phenomenon is well studied in eukaryotes, particularly in humans for …

DNA methylation is a major epigenetic modification that is strongly involved in the
physiological control of genome expression. DNA methylation patterns are largely modified …