Because life is often unpredictable, dynamic, and complex, all animals have evolved
remarkable abilities to cope with changes in their external environment and internal …

It has long been understood that many of the same manipulations that increase longevity in
Caenorhabditis elegans also increase resistance to various acute stressors, and vice-versa; …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Life history theory seeks to explain the evolution of the major features of life cycles by
analyzing the ecological factors that shape age-specific schedules of growth, reproduction …

Several pharmacological, dietary, and genetic interventions that increase mammalian
lifespan are known, but general principles of lifespan extension remain unclear. Here, we …

Curcumin is the active ingredient in the herbal medicine and dietary spice, turmeric
(Curcuma longa). It has a wide range of biological activities, including anti-inflammatory …

Abstract Quercetin, Caffeic-and Rosmarinic acid exposure extend lifespan in Caenorhabditis
elegans. This comparative study uncovers basic common and contrasting underlying …

GH/insulin/IGF-1 signaling is a vital pathway eg in the regulation of protein synthesis and
glucose metabolism. However, mouse dwarf strains which exhibit reduced GH secretion and …

The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved
health and longevity. The precise mechanism (s) responsible for this remains to be …

Aging is a complex process associated with a decline in functionality of adult stem cells
affecting tissue homeostasis and regeneration. Calorie restriction (CR) is the only …