Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

Obesity and aging are two important epidemic factors for metabolic syndrome and many
other health issues, which contribute to devastating diseases such as cardiovascular …

Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors,
including feeding, but less is known about how these circuits may interact. In this study, we …

Brain glucose-sensing neurons detect glucose fluctuations and prevent severe
hypoglycemia, but mechanisms mediating functions of these glucose-sensing neurons are …

Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

Previous studies have shown that AgRP neurons in the arcuate nucleus (ARC) respond to
energy deficits and play a key role in the control of feeding behavior and metabolism. Here …

Previous studies indicate that the activity of hypothalamic POMC neurons can be regulated
by glucose via intracellular mechanisms, but its regulation by lactate is poorly understood. In …

Obesity is primarily a consequence of consuming calories beyond energetic requirements,
but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons …

Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the
hypothalamus is implicated in energy balance control and memory disorders, we …

Background Major depressive disorders (MDD) is one of the most common mental illness in
the world. Recently, brain m 6 A/m (fat mass-and obesity-associated gene Fto) was found …