Hydrogels in biology and medicine: from molecular principles to bionanotechnology

NA Peppas, JZ Hilt, A Khademhosseini… - Advanced …, 2006 - Wiley Online Library
Hydrophilic polymers are the center of research emphasis in nanotechnology because of
their perceived “intelligence”. They can be used as thin films, scaffolds, or nanoparticles in a …

Soft lithography in biology and biochemistry

GM Whitesides, E Ostuni, S Takayama… - Annual review of …, 2001 - annualreviews.org
▪ Abstract Soft lithography, a set of techniques for microfabrication, is based on printing and
molding using elastomeric stamps with the patterns of interest in bas-relief. As a technique …

Microscale technologies for tissue engineering and biology

A Khademhosseini, R Langer… - Proceedings of the …, 2006 - National Acad Sciences
Microscale technologies are emerging as powerful tools for tissue engineering and
biological studies. In this review, we present an overview of these technologies in various …

Patterning proteins and cells using soft lithography

RS Kane, S Takayama, E Ostuni, DE Ingber… - Biomaterials, 1999 - Elsevier
This review describes the pattering of proteins and cells using a non-photolithographic
microfabrication technology, which we callsoft lithography'because it consists of a set of …

Effect of cell–cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells

SN Bhatia, UJ Balis, ML Yarmush… - The FASEB journal, 1999 - Wiley Online Library
Heterotypic cell interaction between parenchymal cells and nonparenchymal neighbors has
been reported to modulate cell growth, migration, and/or differentiation. In both the …

Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels

VL Tsang, AA Chen, LM Cho, KD Jadin… - The FASEB …, 2007 - Wiley Online Library
We have fabricated a hepatic tissue construct using a multilayer photopatterning platform for
embedding cells in hydrogels of complex architecture. We first explored the potential of …

[HTML][HTML] Bioengineered liver models for drug testing and cell differentiation studies

GH Underhill, SR Khetani - Cellular and molecular gastroenterology and …, 2018 - Elsevier
In vitro models of the human liver are important for the following:(1) mitigating the risk of drug-
induced liver injury to human beings,(2) modeling human liver diseases,(3) elucidating the …

Engineering cellular microenvironments to improve cell-based drug testing

K Bhadriraju, CS Chen - Drug discovery today, 2002 - Elsevier
Recent progress in the biology of cell adhesion is enabling cell culture models to better
reproduce in vivo functions. Cues from adhesion to extracellular matrix and neighboring …

Microengineering of cellular interactions

A Folch, M Toner - Annual review of biomedical engineering, 2000 - annualreviews.org
▪ Abstract Tissue function is modulated by an intricate architecture of cells and biomolecules
on a micrometer scale. Until now, in vitro cellular interactions were mainly studied by …

Microfabrication in biology and medicine

J Voldman, ML Gray, MA Schmidt - Annual review of biomedical …, 1999 - annualreviews.org
▪ Abstract Microfabrication uses integrated-circuit manufacturing technology supplemented
by its own processes to create objects with dimensions in the range of micrometers to …