The past, present, and future of chemotherapy with a focus on individualization of drug dosing
L DeRidder, DA Rubinson, R Langer… - Journal of Controlled …, 2022 - Elsevier
While there have been rapid advances in developing new and more targeted drugs to treat
cancer, much less progress has been made in individualizing dosing. Even though the …
cancer, much less progress has been made in individualizing dosing. Even though the …
AXL receptor as an emerging molecular target in colorectal cancer
L De Rosa, R Di Stasi, V Fusco, LD D'Andrea - Drug Discovery Today, 2024 - Elsevier
Highlights•Several lines of preclinical evidence link the Axl/Gas6 protein system to colorectal
cancer.•Axl overexpression is a negative prognostic factor in colorectal cancer.•Drugs …
cancer.•Axl overexpression is a negative prognostic factor in colorectal cancer.•Drugs …
[HTML][HTML] Can immunotherapy reinforce chemotherapy efficacy? a new perspective on colorectal cancer treatment
X He, H Lan, K Jin, F Liu - Frontiers in Immunology, 2023 - frontiersin.org
As one of the main threats to human life (the fourth most dangerous and prevalent cancer),
colorectal cancer affects many people yearly, decreases patients' quality of life, and causes …
colorectal cancer affects many people yearly, decreases patients' quality of life, and causes …
[HTML][HTML] Fluorouracil therapy and DPYD genotype
L Dean, M Kane - 2021 - europepmc.org
Fluorouracil, or 5-flourouracil (5-FU), is a chemotherapy agent that belongs to the drug class
of fluoropyrimidines. When given as an intravenous (IV) solution, 5-FU is used in the …
of fluoropyrimidines. When given as an intravenous (IV) solution, 5-FU is used in the …
[HTML][HTML] Elevated Risk of Fluoropyrimidine-Associated Toxicity in European Patients with DPYD Genetic Polymorphism: A Systematic Review and Meta-Analysis
W Kim, YA Cho, DC Kim, KE Lee - Journal of Personalized Medicine, 2022 - mdpi.com
Background: Fluoropyrimidine is widely used owing to its clinical efficacy, however, patients
with dihydropyrimidine dehydrogenase (DPD) deficiency can experience fluoropyrimidine …
with dihydropyrimidine dehydrogenase (DPD) deficiency can experience fluoropyrimidine …
Comprehensive pharmacogenetic analysis of DPYD, UGT, CDA, and ABCB1 polymorphisms in pancreatic cancer patients receiving mFOLFIRINOX or gemcitabine …
Modified FOLFIRINOX (mFOLFIRINOX) and gemcitabine+ nab-paclitaxel (GemNab)
regimens represent a standard treatment in advanced pancreatic cancer (aPC). DPYD and …
regimens represent a standard treatment in advanced pancreatic cancer (aPC). DPYD and …
New DPYD variants causing DPD deficiency in patients treated with fluoropyrimidine
X García-González, B Kaczmarczyk… - Cancer chemotherapy …, 2020 - Springer
Purpose Several clinical guidelines recommend genetic screening of DPYD, including
coverage of the variants c. 1905+ 1G> A (DPYD* 2A), c. 1679T> G (DPYD* 13), c. 2846A> T …
coverage of the variants c. 1905+ 1G> A (DPYD* 2A), c. 1679T> G (DPYD* 13), c. 2846A> T …
[HTML][HTML] Management of patients with early-stage colon cancer: guidelines of the Italian Medical Oncology Association
L Salvatore, M Imperatori, E Arnoldi, C Carnaghi… - ESMO open, 2020 - Elsevier
About 75% of colorectal cancers are diagnosed as early stage, in which radical surgery is
achievable. In the last decade, in Italy, the overall incidence of colorectal cancer has …
achievable. In the last decade, in Italy, the overall incidence of colorectal cancer has …
Discrepancies between dihydropyrimidine dehydrogenase phenotyping and genotyping: What are the explanatory factors?
C Arrivé, X Fonrose, F Thomas, G Roth… - British Journal of …, 2023 - Wiley Online Library
Aim Dihydropyrimidine dehydrogenase (DPD) deficiency can be detected by phenotyping
(measurement of plasma uracil [U], with U≥ 16 μg/L defining a partial deficiency) and/or by …
(measurement of plasma uracil [U], with U≥ 16 μg/L defining a partial deficiency) and/or by …
[HTML][HTML] The role of dihydropyrimidine dehydrogenase and thymidylate synthase polymorphisms in fluoropyrimidine-based cancer chemotherapy in an Iranian …
MH Abbasian, N Ansarinejad, B Abbasi… - Avicenna journal of …, 2020 - ncbi.nlm.nih.gov
Background: The fluoropyrimidine drug 5-Fluorouracil (5-FU) and the prodrug capecitabine
have been extensively used for treatment of many types of cancer including colorectal …
have been extensively used for treatment of many types of cancer including colorectal …