Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions

NR Pugliese, P Pellicori, F Filidei… - Cardiovascular …, 2022 - academic.oup.com
Many patients with symptoms and signs of heart failure have a left ventricular ejection
fraction≥ 50%, termed heart failure with preserved ejection fraction (HFpEF). HFpEF is a …

[HTML][HTML] Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

X Yin, X Yin, X Pan, J Zhang, X Fan, J Li… - Frontiers in …, 2023 - frontiersin.org
Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

Elabela alleviates ferroptosis, myocardial remodeling, fibrosis and heart dysfunction in hypertensive mice by modulating the IL-6/STAT3/GPX4 signaling

Z Zhang, J Tang, J Song, M Xie, Y Liu, Z Dong… - Free Radical Biology …, 2022 - Elsevier
Hypertension-mediated pathological cardiac remodeling often progresses to heart failure.
Elabela, mainly expressed in the cardiac microvascular endothelial cells (CMVECs) …

Cardiac reserve and exercise capacity: insights from combined cardiopulmonary and exercise echocardiography stress testing

NR Pugliese, N De Biase, L Conte, L Gargani… - Journal of the American …, 2021 - Elsevier
Background Cardiopulmonary exercise testing (CPET) represents the gold standard to
estimate peak oxygen consumption (VO 2) noninvasively. To improve the analysis of the …

New noninvasive methods to evaluate microvascular structure and function

D Rizzoni, A Mengozzi, S Masi, C Agabiti Rosei… - …, 2022 - Am Heart Assoc
The structural and functional alterations of microvessels are detected because of
physiological aging and in several cardiometabolic diseases, including hypertension …

[HTML][HTML] Edema formation in congestive heart failure and the underlying mechanisms

Z Abassi, EE Khoury, T Karram… - Frontiers in cardiovascular …, 2022 - frontiersin.org
Congestive heart failure (HF) is a complex disease state characterized by impaired
ventricular function and insufficient peripheral blood supply. The resultant reduced blood …

The incremental value of multi-organ assessment of congestion using ultrasound in outpatients with heart failure

NR Pugliese, P Pellicori, F Filidei… - European Heart …, 2023 - academic.oup.com
Aims We investigated the prevalence and clinical value of assessing multi-organ congestion
by ultrasound in heart failure (HF) outpatients. Methods and results Ultrasound congestion …

Middle age serum sodium levels in the upper part of normal range and risk of heart failure

NI Dmitrieva, D Liu, CO Wu, M Boehm - European Heart Journal, 2022 - academic.oup.com
Aims With increasing prevalence of heart failure (HF) owing to the ageing population,
identification of modifiable risk factors is important. In a mouse model, chronic hypohydration …

Lifestyle medicine as a treatment for resistant hypertension

F Ribeiro, M Teixeira, AJ Alves, A Sherwood… - Current hypertension …, 2023 - Springer
Abstract Purpose of Review Approximately 10% of the adults with hypertension fail to
achieve the recommended blood pressure treatment targets on 3 antihypertensive …

[HTML][HTML] Mitochondrial effects of common cardiovascular medications: the good, the bad and the mixed

AM Bețiu, L Noveanu, IM Hâncu, A Lascu… - International Journal of …, 2022 - mdpi.com
Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …