[HTML][HTML] Role of fibroblasts in wound healing and tissue remodeling on Earth and in space

F Cialdai, C Risaliti, M Monici - Frontiers in bioengineering and …, 2022 - frontiersin.org
Wound healing (WH) and the role fibroblasts play in the process, as well as healing
impairment and fibroblast dysfunction, have been thoroughly reviewed by other authors. We …

Neuro-consequences of the spaceflight environment

SD Mhatre, J Iyer, S Puukila, AM Paul… - Neuroscience & …, 2022 - Elsevier
As human space exploration advances to establish a permanent presence beyond the Low
Earth Orbit (LEO) with NASA's Artemis mission, researchers are striving to understand and …

[HTML][HTML] Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight

JK Kim, BT Tierney, EG Overbey, E Dantas… - Nature …, 2024 - nature.com
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …

[HTML][HTML] Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

F Wu, H Du, E Overbey, JK Kim, P Makhijani… - Nature …, 2024 - nature.com
Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …

[HTML][HTML] Wide range applications of spirulina: from earth to space missions

G Fais, A Manca, F Bolognesi, M Borselli, A Concas… - Marine Drugs, 2022 - mdpi.com
Spirulina is the most studied cyanobacterium species for both pharmacological applications
and the food industry. The aim of the present review is to summarize the potential benefits of …

Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells

CJ Gallardo-Dodd, C Oertlin, J Record, RG Galvani… - Science …, 2023 - science.org
The next steps of deep space exploration are manned missions to Moon and Mars. For safe
space missions for crew members, it is important to understand the impact of space flight on …

[HTML][HTML] The impact of microgravity on immunological states

J Hicks, M Olson, C Mitchell, CM Juran, AM Paul - Immunohorizons, 2023 - journals.aai.org
As we explore other planetary bodies, astronauts will face unique environmental and
physiological challenges. The human immune system has evolved under Earth's …

[HTML][HTML] Multi-system responses to altered gravity and spaceflight: Insights from Drosophila melanogaster

J Iyer, SD Mhatre, R Gilbert, S Bhattacharya - … & Biobehavioral Reviews, 2022 - Elsevier
NASA is planning to resume human-crewed lunar missions and lay the foundation for
human exploration to Mars. However, our knowledge of the overall effects of long-duration …

[HTML][HTML] Space radiation damage rescued by inhibition of key spaceflight associated miRNAs

JT McDonald, JK Kim, L Farmerie, ML Johnson… - Nature …, 2024 - nature.com
Our previous research revealed a key microRNA signature that is associated with
spaceflight that can be used as a biomarker and to develop countermeasure treatments to …

[HTML][HTML] Effects of low dose space radiation exposures on the splenic metabolome

EC Laiakis, I Shuryak, A Deziel, YW Wang… - International journal of …, 2021 - mdpi.com
Future space missions will include a return to the Moon and long duration deep space
roundtrip missions to Mars. Leaving the protection that Low Earth Orbit provides will …