Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …

Abstract T-cell receptor (TCR)-based adoptive therapy employs genetically modified
lymphocytes that are directed against specific tumor markers. This therapeutic modality …

Most studies on genetic engineering technologies for cancer immunotherapy based on
allogeneic donors have focused on adaptive immunity. However, the main limitation of such …

Recent development of methods to discover and engineer therapeutic T‐cell receptors
(TCRs) or antibody mimics of TCRs, and to understand their immunology and …

T cell receptor-engineered T (TCR-T) cells targeting neoantigens present potential
immunotherapy for solid tumors. With the continuous optimization of the entire production …

Immune checkpoint inhibitors have redefined the treatment of cancer, but their efficacy
depends critically on the presence of sufficient tumor-specific lymphocytes, and cellular …

Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues.
Many are chemo-and radiotherapy resistant, thus conventional treatments fail to increase …

Bioreactors are essential tools for the development of efficient and high-quality cell therapy
products. However, their application is far from full potential, holding several challenges …

Simple Summary The incidence of metastatic melanoma has been increasing over the past
years with current therapies showing limited efficacy to cure the disease. Therefore, other …

Natural killer (NK) cells can be widely applied for cancer immunotherapy due to their ability
to lyse tumor targets without prior sensitization or human leukocyte antigens-matching …