Background Catheter-based pulmonary vein isolation is an effective treatment for
paroxysmal atrial fibrillation. Pulsed field ablation, which delivers microsecond high-voltage …

In the last three decades, ablation of atrial fibrillation (AF) has become an evidence-based
safe and efficacious treatment for managing the most common cardiac arrhythmia. In 2007 …

Background Pulsed field ablation (PFA) induces cell death through electroporation using
ultrarapid electrical pulses. We sought to compare the procedural efficiency characteristics …

Aims Pulsed field ablation (PFA) has emerged as a promising alternative to thermal ablation
for treatment of atrial fibrillation (AF). We report performance and safety using the …

The mechanisms of cell death due to electroporation are still not well understood. Recent
studies suggest that cell death due to electroporation is not an immediate all-or-nothing …

Clinical outcomes of catheter ablation for atrial fibrillation (AF) are suboptimal due, in part, to
challenges in achieving durable lesions. Although focal point-by-point ablation allows for the …

Methods In the study, lesions were generated by applying IRE in porcine and human left
ventricles using a pair of parallel needle electrodes at different voltages (500–1500 V) and …

Background We investigated the preclinical safety and efficacy of ventricular pulsed field
ablation (PFA) using a family of novel, 6-/8-Fr, linear, and spiral PFA/mapping catheters …

Background The ADVENT randomized trial revealed no significant difference in 1-year
freedom from atrial arrhythmias (AA) between thermal (RF/Cryo) and pulsed field ablation …

Introduction Pulmonary vein isolation (PVI) remains the cornerstone in the treatment of atrial
fibrillation (AF). PVI using cryoballoon (CB) technology has emerged as a standard …