It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …

Reproductive aging is characterized by a decline in oocyte quantity and quality, which is
directly associated with a decline in reproductive potential, as well as poorer reproductive …

Scope Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder
that can cause infertility; however, the underlying mechanisms remain ill‐defined, and there …

BACKGROUND DNA integrity and stability are critical determinants of cell viability. This is
especially true in the female germline, wherein DNA integrity underpins successful …

One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which
is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged …