At present, there is no cure for asthma, and treatment typically involves therapies that
prevent or reduce asthma symptoms, without modifying the underlying disease. A “disease …

Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the
terminal bronchioles. In utero, spontaneous phasic contraction of fetal ASM is critical for …

Abstract The Saudi Initiative for Asthma 2021 (SINA-2021) is the fifth version of asthma
guidelines for the diagnosis and management of asthma for adults and children, which is …

Background Asthma is a heterogeneous disease with differences in onset, severity, and
inflammation. Bronchial epithelial cells (BECs) contribute to asthma pathophysiology …

Bronchial thermoplasty is a relatively new but seemingly effective treatment in subjects with
asthma who do not respond to conventional therapy. Although the favored mechanism is …

Bronchial thermoplasty (BT) is a bronchoscopic treatment for patients with severe asthma
who remain symptomatic despite optimal medical therapy. In this “expert best practice” …

Although a minority of asthma patients suffer from severe asthma, they represent a major
clinical challenge in terms of poor symptom control despite high-dose treatment, risk of …

This is the fourth version of the updated guidelines for the diagnosis and management of
asthma, developed by the Saudi Initiative for Asthma (SINA) group, a subsidiary of the Saudi …

Background Bronchial thermoplasty (BT) has shown favorable safety and efficacy in several
randomized controlled trials (RCTs), but has not been directly compared to biological …

Background Phenotypes and endotypes predicting optimal response to bronchial
thermoplasty (BT) in patients with severe asthma remain elusive. Objective Our aim was to …