Purinergic signaling plays important roles in control of vascular tone and remodeling. There
is dual control of vascular tone by ATP released as a cotransmitter with noradrenaline from …

This review is a historical account about purinergic signalling in the heart, for readers to see
how ideas and understanding have changed as new experimental results were published …

There are nineteen different receptor proteins for adenosine, adenine and uridine
nucleotides, and nucleotide sugars, belonging to three families of G protein-coupled …

Epithelial cells participate in the immune response of the intestinal mucosa. Extracellular
nucleotides have been recognized as inflammatory molecules. We investigated the role of …

Rationale: Extracellular nucleotides have recently been identified as proinflammatory
mediators involved in asthma pathogenesis by signaling via purinergic receptors, but the …

ATP and UTP are endogenous agonists of P2Y2/4 receptors. To define the in vivo effects of
P2Y2 receptor activation on blood pressure and urinary excretion, we compared the …

Aims UDP-sugars can act as extracellular signalling molecules, but relatively little is known
about their cardiovascular actions. The P2Y 14 receptor is a G i/o-coupled receptor which is …

ATP is an important neurotransmitter being released with noradrenaline (NA) and
neuropeptide Y (NPY) from perivascular sympathetic nerves; it acts at postjunctional P2X …

Bladder dysfunction characterized by abnormal bladder smooth muscle (BSM) contractions
is pivotal to the disease process in overactive bladder, urge incontinence, and spinal cord …

Vasopressin is an essential hormone involved in the maintenance of cardiovascular
homeostasis. It has been in use therapeutically for many decades, with an emphasis on its …