Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA-and glutamatergic alterations

YT Hu, ZL Tan, D Hirjak, G Northoff - Molecular Psychiatry, 2023 - nature.com
The excitation-inhibition (E/I) imbalance is an important molecular pathological feature of
major depressive disorder (MDD) as altered GABA and glutamate levels have been found in …

Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies

B Bi, D Che, Y Bai - Translational Psychiatry, 2022 - nature.com
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in
three domains including emotional processing, cognitive processing, and psychomotor …

Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology

JP Rogers, MA Oldham, G Fricchione… - Journal of …, 2023 - journals.sagepub.com
The British Association for Psychopharmacology developed an evidence-based consensus
guideline on the management of catatonia. A group of international experts from a wide …

The neural signature of psychomotor disturbance in depression

F Wüthrich, S Lefebvre, VA Mittal, SA Shankman… - Molecular …, 2024 - nature.com
Up to 70% of patients with major depressive disorder present with psychomotor disturbance
(PmD), but at the present time understanding of its pathophysiology is limited. In this study …

[HTML][HTML] Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium

N Javaheripour, M Li, T Chand, A Krug… - Translational …, 2021 - nature.com
Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be
measured by assessing functional connectivity (FC) at resting-state functional MRI, that may …

Altered effective connectivity in sensorimotor cortices is a signature of severity and clinical course in depression

D Ray, D Bezmaternykh, M Mel'nikov… - Proceedings of the …, 2021 - National Acad Sciences
Functional neuroimaging research on depression has traditionally targeted neural networks
associated with the psychological aspects of depression. In this study, instead, we focus on …

A unified model of the pathophysiology of bipolar disorder

P Magioncalda, M Martino - Molecular Psychiatry, 2022 - nature.com
This work provides an overview of the most consistent alterations in bipolar disorder (BD),
attempting to unify them in an internally coherent working model of the pathophysiology of …

Spatiotemporal Psychopathology–An integrated brain-mind approach and catatonia

G Northoff, D Hirjak - Schizophrenia research, 2022 - Elsevier
Catatonia is featured by complex symptoms combining motor, affective and behavioral
phenomena as well as by its syndrome character with trans-diagnostic occurrence. It …

Enhanced default mode network functional connectivity links with electroconvulsive therapy response in major depressive disorder

Y Pang, Q Wei, S Zhao, N Li, Z Li, F Lu, J Pang… - Journal of Affective …, 2022 - Elsevier
Background Electroconvulsive therapy (ECT) is an effective neuromodulatory treatment for
major depressive disorder (MDD), especially for cases resistant to antidepressant drugs …

Is depression a global brain disorder with topographic dynamic reorganization?

G Northoff, D Hirjak - Translational Psychiatry, 2024 - nature.com
Major depressive disorder (MDD) is characterized by a multitude of psychopathological
symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal …