Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA-and glutamatergic alterations
YT Hu, ZL Tan, D Hirjak, G Northoff - Molecular Psychiatry, 2023 - nature.com
The excitation-inhibition (E/I) imbalance is an important molecular pathological feature of
major depressive disorder (MDD) as altered GABA and glutamate levels have been found in …
major depressive disorder (MDD) as altered GABA and glutamate levels have been found in …
Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies
B Bi, D Che, Y Bai - Translational Psychiatry, 2022 - nature.com
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in
three domains including emotional processing, cognitive processing, and psychomotor …
three domains including emotional processing, cognitive processing, and psychomotor …
Evidence-based consensus guidelines for the management of catatonia: Recommendations from the British Association for Psychopharmacology
The British Association for Psychopharmacology developed an evidence-based consensus
guideline on the management of catatonia. A group of international experts from a wide …
guideline on the management of catatonia. A group of international experts from a wide …
The neural signature of psychomotor disturbance in depression
Up to 70% of patients with major depressive disorder present with psychomotor disturbance
(PmD), but at the present time understanding of its pathophysiology is limited. In this study …
(PmD), but at the present time understanding of its pathophysiology is limited. In this study …
[HTML][HTML] Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium
Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be
measured by assessing functional connectivity (FC) at resting-state functional MRI, that may …
measured by assessing functional connectivity (FC) at resting-state functional MRI, that may …
Altered effective connectivity in sensorimotor cortices is a signature of severity and clinical course in depression
D Ray, D Bezmaternykh, M Mel'nikov… - Proceedings of the …, 2021 - National Acad Sciences
Functional neuroimaging research on depression has traditionally targeted neural networks
associated with the psychological aspects of depression. In this study, instead, we focus on …
associated with the psychological aspects of depression. In this study, instead, we focus on …
A unified model of the pathophysiology of bipolar disorder
P Magioncalda, M Martino - Molecular Psychiatry, 2022 - nature.com
This work provides an overview of the most consistent alterations in bipolar disorder (BD),
attempting to unify them in an internally coherent working model of the pathophysiology of …
attempting to unify them in an internally coherent working model of the pathophysiology of …
Spatiotemporal Psychopathology–An integrated brain-mind approach and catatonia
G Northoff, D Hirjak - Schizophrenia research, 2022 - Elsevier
Catatonia is featured by complex symptoms combining motor, affective and behavioral
phenomena as well as by its syndrome character with trans-diagnostic occurrence. It …
phenomena as well as by its syndrome character with trans-diagnostic occurrence. It …
Enhanced default mode network functional connectivity links with electroconvulsive therapy response in major depressive disorder
Y Pang, Q Wei, S Zhao, N Li, Z Li, F Lu, J Pang… - Journal of Affective …, 2022 - Elsevier
Background Electroconvulsive therapy (ECT) is an effective neuromodulatory treatment for
major depressive disorder (MDD), especially for cases resistant to antidepressant drugs …
major depressive disorder (MDD), especially for cases resistant to antidepressant drugs …
Is depression a global brain disorder with topographic dynamic reorganization?
G Northoff, D Hirjak - Translational Psychiatry, 2024 - nature.com
Major depressive disorder (MDD) is characterized by a multitude of psychopathological
symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal …
symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal …