[HTML][HTML] Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics

DV Bhalani, B Nutan, A Kumar, AK Singh Chandel - Biomedicines, 2022 - mdpi.com
The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

[HTML][HTML] Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery

AB Buya, A Beloqui, PB Memvanga, V Préat - Pharmaceutics, 2020 - mdpi.com
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

[HTML][HTML] Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs

X Zhang, H Xing, Y Zhao, Z Ma - Pharmaceutics, 2018 - mdpi.com
Over the past decades, a large number of drugs as well as drug candidates with poor
dissolution characteristics have been witnessed, which invokes great interest in enabling …

Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self‐emulsifying systems

S Gupta, R Kesarla, A Omri - International Scholarly Research …, 2013 - Wiley Online Library
Poorly water‐soluble drug candidates are becoming more prevalent. It has been estimated
that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous …

Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances

AA Date, N Desai, R Dixit, M Nagarsenker - Nanomedicine, 2010 - Taylor & Francis
There has been a resurgence of interest in nanoemulsions for various pharmaceutical
applications since low-energy emulsification methods, such as spontaneous or self …

Self nanoemulsifying drug delivery system (SNEDDS) of rosuvastatin calcium: design, formulation, bioavailability and pharmacokinetic evaluation

K Balakumar, CV Raghavan, S Abdu - Colloids and Surfaces B …, 2013 - Elsevier
The aim of the present study is to improve solubility and bioavailability of Rosuvastatin
calcium using self nanoemulsifying drug delivery system (SNEDDS). Self emulsifying …

New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

A Müllertz, A Ogbonna, S Ren… - Journal of pharmacy and …, 2010 - academic.oup.com
Objectives The aim of this review is to highlight relevant considerations when implementing
a rational strategy for the development of lipid and surfactant based drug delivery system …

SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization

EB Basalious, N Shawky, SM Badr-Eldin - International journal of …, 2010 - Elsevier
The aim of this study was to develop and optimize SNEDDS formulations containing
surfactants reported to be bioenhancers for improvement of dissolution and oral absorption …

[HTML][HTML] Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: design, formulation, pharmacokinetic and …

A Nasr, A Gardouh, M Ghorab - Pharmaceutics, 2016 - mdpi.com
The main purpose of this study was to develop a solid self-nanoemulsifying drug delivery
system (S-SNEDDS) of Olmesartan (OLM) for enhancement of its solubility and dissolution …

[HTML][HTML] Impact of process parameters in the generation of novel aspirin nanoemulsions–comparative studies between ultrasound cavitation and microfluidizer

SY Tang, P Shridharan, M Sivakumar - Ultrasonics sonochemistry, 2013 - Elsevier
In the present investigation, the operating efficiency of a bench-top air-driven microfluidizer
has been compared to that of a bench-top high power ultrasound horn in the production of …