Takifugu rubripes is a classical model organism for studying the role of gonad
organogenesis in such physiological processes as fertilization, sex determination, and …

The collagen type I alpha 1 chain (COL1A1), as a major component of extracellular matrix,
plays a potential role in the growth and development of bovine follicles. However, its specific …

Delaying childbearing age has become a trend in modern times, but it has also led to a
common challenge in clinical reproductive medicine—diminished ovarian reserve (DOR) …

The oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth
differentiation factor 9 (GDF9) interact functionally, and it is hypothesized that this interaction …

Polyspermy or the penetration of more than one sperm cell remains a problem during
porcine in vitro fertilization (IVF). After in vitro culture of porcine zygotes, only a low …

Cumulus expansion is necessary for the release of a fertilizable oocyte from the ovary, which
is critical for the normal fertilization of mammals. Cumulus expansion requires cooperation …

Background Development of ovarian follicles is regulated by a complex interaction of intra‐
and extra‐follicular signals. Oocyte‐derived paracrine factors (ODPFs) play a central role in …

Both TGF‐β/SMAD4 signaling pathway and HAS2–HA system have been shown to control
granulosa cell (GC) state in mammalian ovary. However, the regulatory relationship …

Mammalian oocytes develop and mature in a mutually dependent relationship with
surrounding cumulus cells. The oocyte actively regulates cumulus cell differentiation and …

The surge in luteinizing hormone (LH) in preovulatory ovarian follicles triggers the
resumption of oocyte meiosis accompanied by expansion of surrounding cumulus cells and …