Mental disorders represent a worldwide public health concern. Psychotherapies and
pharmacotherapies are recommended as first line treatments. However, evidence has …

An important step when designing an empirical study is to justify the sample size that will be
collected. The key aim of a sample size justification for such studies is to explain how the …

Restoration of human brain function after injury is a signal challenge for translational
neuroscience. Rodent stroke recovery studies identify an optimal or sensitive period for …

Individuals with substance use disorders (SUDs) are at increased risk for COVID‐19
infection and for adverse outcomes of the infection. Though vaccines are highly effective …

Background The aim of this systematic review is to describe the different types of anchors
and statistical methods used in estimating the Minimal Clinically Important Difference (MCID) …

The role of the Tear Film and Ocular Surface Society (TFOS) Dry Eye Workshop (DEWS) II
Diagnostic Methodology Subcommittee was 1) to identify tests used to diagnose and monitor …

Background The association between physical activity, sedentary behavior and health-
related quality of life in children and adolescents has been mostly investigated in those …

Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

Background: Few measures capture the complex symptoms and concerns of those receiving
palliative care. Aim: To validate the Integrated Palliative care Outcome Scale, a measure …

This open access book is the first published guide about how to analyse data produced by
the EQ-5D, one of the most widely used Patient Reported Outcomes questionnaires world …