Changing demographics make it ever more important to understand the modifiable risk
factors for disability and loss of independence with advancing age. For more than two …

Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced …

Background Myostatin inhibits skeletal muscle growth. The humanised monoclonal antibody
LY2495655 (LY) binds and neutralises myostatin. We aimed to test whether LY increases …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

Both acquired and inherited disorders of muscle are common; thus, greater understanding of
muscle growth and maintenance is important for future therapies. Myostatin down-regulates …

Muscle performance is influenced by turnover of contractile proteins. Production of new
myofibrils and degradation of existing proteins is a delicate balance, which, depending on …

▪ Abstract Myostatin is a secreted protein that acts as a negative regulator of skeletal muscle
mass. During embryogenesis, myostatin is expressed by cells in the myotome and in …

Satellite cells are quiescent muscle stem cells that promote postnatal muscle growth and
repair. Here we show that myostatin, a TGF-β member, signals satellite cell quiescence and …

The myostatin/activin type II receptor (ActRII) pathway has been identified to be critical in
regulating skeletal muscle size. Several other ligands, including GDF11 and the activins …

Loss of muscle mass occurs in a variety of diseases, including cancer, chronic heart failure,
aquired immunodeficiency syndrome, diabetes, and renal failure, often aggravating …