The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …

The use of in vitro tools to study trophoblast differentiation and function is essential to
improve understanding of normal and abnormal placental development. The relative …

Despite the recent advances in artificial tissue and organ engineering, how to generate
large size viable and functional complex organs still remains as a grand challenge for …

In vitro derivation of pancreatic β-cells from human pluripotent stem cells holds promise as
diabetes treatment. Despite recent progress, efforts to generate physiologically competent β …

The interplay between pancreatic epithelium and the surrounding microenvironment is
pivotal for pancreas formation and differentiation as well as adult organ homeostasis. The …

Perfusion-independent regulation of epithelial pattern formation by the vasculature during
organ development and regeneration is of considerable interest for application in restoring …

The mammalian pancreas is a branched organ that does not exhibit stereotypic branching
patterns, similarly to most other glands. Inside branches, it contains a network of ducts that …

Generating comprehensive image maps, while preserving spatial three-dimensional (3D)
context, is essential in order to locate and assess quantitatively specific cellular features and …

Organogenesis requires tightly coordinated and patterned growth of numerous cell types to
form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels …

Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and
cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of …