Combining precision radiotherapy with molecular targeting and immunomodulatory agents: a guideline by the American Society for Radiation Oncology
RG Bristow, B Alexander, M Baumann… - The Lancet …, 2018 - thelancet.com
The practice of radiation oncology is primarily based on precise technical delivery of highly
conformal, image-guided external beam radiotherapy or brachytherapy. However …
conformal, image-guided external beam radiotherapy or brachytherapy. However …
Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date
JIL Bastien, KA McNeill, HA Fine - Cancer, 2015 - Wiley Online Library
During the last decade, extensive multiplatform genome‐wide analysis has yielded a wealth
of knowledge regarding the genetic and molecular makeup of glioblastoma multiforme …
of knowledge regarding the genetic and molecular makeup of glioblastoma multiforme …
Safety and efficacy of depatuxizumab mafodotin + temozolomide in patients with EGFR-amplified, recurrent glioblastoma: results from an international phase I …
AB Lassman, MJ Van Den Bent, HK Gan… - Neuro …, 2019 - academic.oup.com
Background Patients with glioblastoma (GBM) have a dismal prognosis. Nearly all will
relapse with no clear standard of care for recurrent disease (rGBM). Approximately 50% of …
relapse with no clear standard of care for recurrent disease (rGBM). Approximately 50% of …
Pediatric high‐grade glioma: moving toward subtype‐specific multimodal therapy
HV Chatwin, J Cruz Cruz, AL Green - The FEBS journal, 2021 - Wiley Online Library
Pediatric high‐grade gliomas (pHGG) comprise a deadly, heterogenous category of
pediatric gliomas with a clear need for more effective treatment options. Advances in high …
pediatric gliomas with a clear need for more effective treatment options. Advances in high …
EGFR, the Lazarus target for precision oncology in glioblastoma
B Lin, J Ziebro, E Smithberger, KR Skinner… - Neuro …, 2022 - academic.oup.com
The Lazarus effect is a rare condition that happens when someone seemingly dead shows
signs of life. The epidermal growth factor receptor (EGFR) represents a target in the fatal …
signs of life. The epidermal growth factor receptor (EGFR) represents a target in the fatal …
[HTML][HTML] Glioblastoma therapy: past, present and future
E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …
Although great efforts have been made by clinicians and researchers, no significant …
[HTML][HTML] Autophagic and apoptotic pathways as targets for chemotherapy in glioblastoma
C Trejo-Solís, N Serrano-Garcia… - International journal of …, 2018 - mdpi.com
Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a
mean life expectancy of less than 15 months. This is due in part to the high resistance to …
mean life expectancy of less than 15 months. This is due in part to the high resistance to …
Antibody–drug conjugates in glioblastoma therapy: the right drugs to the right cells
HK Gan, M van den Bent, AB Lassman… - Nature reviews Clinical …, 2017 - nature.com
Glioblastomas are high-grade brain tumours with a poor prognosis and, currently, few
available therapeutic options. This lack of effective treatments has been linked to diverse …
available therapeutic options. This lack of effective treatments has been linked to diverse …
[HTML][HTML] Anoikis resistance in diffuse glioma: The potential therapeutic targets in the future
Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and
a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis …
a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis …
[HTML][HTML] Targeting glioblastoma stem cells to overcome chemoresistance: an overview of current therapeutic strategies
Glioblastoma (GBM) is the most malignant primary brain tumor. The current standard
approach in GBM is surgery, followed by treatment with radiation and temozolomide (TMZ); …
approach in GBM is surgery, followed by treatment with radiation and temozolomide (TMZ); …