Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

Cancer cells are commonly subjected to endoplasmic reticulum (ER) stress. To gain survival
advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such …

Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …

The transcriptomic classification of glioblastoma (GBM) has failed to predict survival and
therapeutic vulnerabilities. A computational approach for unbiased identification of core …

Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large
family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif …

Chromosomal translocations that generate in-frame oncogenic gene fusions are notable
examples of the success of targeted cancer therapies,,. We have previously described gene …

Glioblastoma multiform (GBM) is the most common brain tumor characterized by a dismal
prognosis. GBM cancer stem cells (gCSC) or tumor-initiating cells are the cell population …

DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has
been implicated in several pathologies of Down syndrome (DS), including cognitive deficits …