▪ Abstract Regulation of tyrosine phosphorylation is a critical control point for integration of
environmental signals into cellular responses. This regulation is mediated by the reciprocal …

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral
genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs …

The possibility of HIV-1 eradication has been limited by the existence of latently infected
cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have …

In evaluating current combination drug regimens for treatment of human immunodeficiency
virus (HIV) disease, it is important to determine the existence of viral reservoirs. After …

To understand the high variability of the asymptomatic interval between primary human
immunodeficiency virus type 1 (HIV-1) infection and the development of AIDS, we studied …

CCR5 and CXCR4 are the major HIV-1 coreceptors for R5 and X4 HIV-1 strains,
respectively, and a threshold number of CD4 and chemokine receptor molecules is required …

Identification of T-cell subsets that are infected in vivo is essential to understanding the
pathogenesis of human immunodeficiency virus (HIV) disease; however, this goal has been …

Binding of the HIV envelope to the chemokine coreceptors triggers membrane fusion and
signal transduction. The fusion process has been well characterized, yet the role of …

Viral dynamics were intensively investigated in eight patients with acute HIV infection to
define the earliest rates of change in plasma HIV RNA before and after the start of …

Abstract Treatment of HIV-1-infected individuals with a combination of anti-retroviral agents
results in sustained suppression of HIV-1 replication, as evidenced by a reduction in plasma …