Another one fights the dust: targeting the NLRP3 inflammasome for the treatment of silicosis

M Lam, A Mansell, MD Tate - American journal of respiratory cell …, 2022 - atsjournals.org
Silicosis is a multifaceted lung disease, characterized by persistent inflammation and
structural remodeling. Despite its poor prognosis, there are no treatments currently available …

[HTML][HTML] The role of the NLRP3 inflammasome in mediating glomerular and tubular injury in diabetic nephropathy

BM Williams, CL Cliff, K Lee, PE Squires… - Frontiers in …, 2022 - frontiersin.org
The NOD-like receptor protein 3 (NLRP3) inflammasome is a multi-protein signalling
complex integral to the chronic inflammatory response, activated in response to sterile and …

[HTML][HTML] Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling …

Q Tang, C Xing, M Li, Q Jia, C Bo, Z Zhang - … and environmental safety, 2022 - Elsevier
Macrophages play an important role in causing silicosis eventually becoming an irreversible
fibrotic disease, and there are no specific drugs for silicosis in the clinic so far. Pirfenidone …

Emerging trends in silicosis research: a scientometric review

X RenChen, W Wang, Y Lu - Environmental Science and Pollution …, 2023 - Springer
Silicosis is a global disease whose prevention efforts cannot be ignored today. Although
numerous silicosis-related data have been published recently, emphasizing the …

[HTML][HTML] From Basic Research to Clinical Practice: Considerations for Treatment Drugs for Silicosis

R Li, H Kang, S Chen - International Journal of Molecular Sciences, 2023 - mdpi.com
Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public
health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis …

[HTML][HTML] Thalidomide alleviates pulmonary fibrosis induced by silica in mice by inhibiting ER stress and the TLR4-NF-κB pathway

Y Li, W Cai, F Jin, X Wang, W Liu, T Li, X Yang… - International Journal of …, 2022 - mdpi.com
Silicosis is the most prevalent occupational disease in China. It is a form of pulmonary
fibrosis caused by the inhalation of silicon particles. As there is no cure for the potentially …

Component analysis and anti-pulmonary fibrosis effects of Rosa sterilis juice

L Wang, Y Li, R Xia, X Zheng, X Li, S Wu, Q Zhang… - Food & Function, 2022 - pubs.rsc.org
Rosa sterilis is a new variety of Rosa roxburghii Tratt, and is rich in bioactive substances, but
its role in pulmonary fibrosis has not been elucidated. The purpose of this study was to …

[HTML][HTML] FcεRI deficiency alleviates silica-induced pulmonary inflammation and fibrosis

Y Chen, M Song, Z Li, L Hou, H Zhang, Z Zhang… - Ecotoxicology and …, 2022 - Elsevier
Silicosis is one of the most important occupational diseases worldwide, caused by inhalation
of silica particles or free crystalline silicon dioxide. As a disease with high mortality, it has no …

Anti-inflammatory protein TSG-6 secreted by BMSCs attenuates silica-induced acute pulmonary inflammation by inhibiting NLRP3 inflammasome signaling in …

W Su, Q Nong, J Wu, R Fan, Y Liang, A Hu… - International Journal of …, 2023 - Elsevier
Silicosis is a severe occupational lung disease caused by inhalation of silica particles.
Unfortunately, there are currently limited treatment options available for silicosis. Recent …

[HTML][HTML] The role of inflammation in silicosis

TT Liu, HF Sun, YX Han, Y Zhan… - Frontiers in Pharmacology, 2024 - frontiersin.org
Silicosis is a chronic illness marked by diffuse fibrosis in lung tissue resulting from
continuous exposure to SiO2-rich dust in the workplace. The onset and progression of …