The long non-coding RNA (lncRNA) PVT1 was first found to activate variant translocations in
the plasmacytoma of mice. Human lncPVT1 is located on chromosome 8q24. 21, at the …

High expression of Aurora kinase A (Aurora-A) has been found to confer cancer cell radio-
and chemoresistance, however, the underlying mechanism is unclear. In this study, by using …

The chromatin-associated proteome (chromatome) regulates cellular gene expression by
restricting access of transcriptional machinery to template DNA, and dynamic re-modeling of …

Infiltrating ductal adenocarcinoma of the pancreas is a real enigma. On one hand, it is one of
the most deadly of all of the solid malignancies. On the other hand, the neoplastic glands …

Patients with human papillomavirus-positive squamous cell carcinoma of the head and neck
(HPV+ HNSCC) have a favorable prognosis compared to those with HPV-negative (HPV−) …

Simple Summary Radiotherapy is the main treatment for cervical cancer patients in
advanced stages. However a considerable number of patients are not sensitive to …

Here, we present a functional assay to detect the repair switch to the alternative PARP1‐
dependent end joining (PARP1‐EJ) pathway and the associated susceptibility to PARPi …

Simple Summary Head and neck cancers (HNSCCs), especially in the advanced stages, are
predominantly treated by radiochemotherapy, including cisplatin. The cure rates are clearly …

Ataxia telangiectasia mutated (ATM) is activated upon DNA double strand breaks (DSBs)
and phosphorylates numerous DSB response proteins, including histone H2AX on serine …

Purpose The aim of this study was to elucidate the impact of DNA damage response (DDR)
proteins 53BP1 and BRCA1 on the double-strand break (DSB)-repair choice. This is …