PROCESSING OF 3′-BLOCKED DNA DOUBLE-STRAND BREAKS BY TYROSYL-DNA PHOSPHODIESTERASE 1, ARTEMIS AND POLYNUCLEOTIDE KINASE …
AS Kawale - 2018 - scholarscompass.vcu.edu
DNA double-strand breaks (DSBs) containing unligatable termini are potent cytotoxic
lesions leading to growth arrest or cell death. The Artemis nuclease and tyrosyl-DNA …
lesions leading to growth arrest or cell death. The Artemis nuclease and tyrosyl-DNA …
[图书][B] A gene association study to identify novel pancreatic cancer susceptibility genes
C Wong - 2017 - search.proquest.com
Approximately 10% of pancreatic cancer (PAC) cases are hereditary in nature, however,
only a fraction is explained by known susceptibility genes. Recent efforts using Next …
only a fraction is explained by known susceptibility genes. Recent efforts using Next …
Novel functions of MCL-1 in ATM signalling, homologous recombination, and heterochromatin dynamics
E Pesarchuk - 2016 - open.library.ubc.ca
MCL‑1 is a pro-survival member of the BCL-2 family of proteins that is over-expressed in a
wide variety of human cancers. Beyond its canonical role regulating apoptosis, our lab was …
wide variety of human cancers. Beyond its canonical role regulating apoptosis, our lab was …
A High Throughput RNAi Screen Reveals the Protein Kinase NEK8 Regulates Replication Fork Protection via the DNA Repair Protein RAD51
A Abeyta - 2016 - digital.lib.washington.edu
Proteins essential for homologous recombination play a pivotal role in the repair of DNA
double strand breaks, DNA inter-strand crosslinks and replication fork stability. Defects in …
double strand breaks, DNA inter-strand crosslinks and replication fork stability. Defects in …
Targeting DNA damage response via miRNAs to enhance radiosensitivity
H Helal - 2016 - ediss.sub.uni-hamburg.de
Tumor cells use a different signaling pathways to repair damage and prevent the cytotoxic
effects of anticancer agents. specific targeting of these signaling pathways enhance tumor …
effects of anticancer agents. specific targeting of these signaling pathways enhance tumor …
The Role of the ATR-CHEK1 Pathway in Therapeutic Resistance Resulting from Distal 11q Loss in Carcinoma Cells
M Sankunny - 2013 - d-scholarship.pitt.edu
One of the biggest public health problems worldwide is death from cancer as a result of
tumor resistance to therapy. Our lab has determined that one form of therapeutic resistance …
tumor resistance to therapy. Our lab has determined that one form of therapeutic resistance …