Objective Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for
biomechanical reasons. Here we provide an additional perspective by discussing how …

Metabolomics is a branch of 'omics' sciences that utilises a couple of analytical tools for the
identification of small molecules (metabolites) in a given sample. The overarching goal of …

Background Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is
the leading cause of pain and disability in the aged population. However, the underlying …

Background Emerging evidence suggests that microRNAs (miRs) are associated with the
progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p derived …

Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering
approaches are primarily based on collagen type I devices that are associated with …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of people
worldwide. Symptom-alleviating treatments exist, although none with long-term efficacy …

Objective Osteoarthritis (OA) is a multifactorial disease with etiological heterogeneity. The
objective of this study was to classify OA subgroups by generating metabolomic phenotypes …

The gut microbiome impacts bone mass, which implies a disruption to bone homeostasis.
However, it is not yet clear how the gut microbiome affects the regulation of bone mass and …

Purpose Osteoarthritis (OA) is a joint disease that is clinically diagnosed using components
of history, physical exam, and characteristic radiographic findings, such as joint space …

To address the complexity of osteoarthritis, integration of multitissue analyses by multiomics
approaches with the inclusion of longitudinal clinical data is necessary for a comprehensive …