Sedation and analgesia are considered by many gas-troenterologists to be an integral
component of the endoscopic examination. For example, more than 98% of endoscopists in …

The ability to deliver safe and effective moderate sedation is crucial to the ability to perform
invasive procedures. Sedative drugs should have a quick onset of action, provide rapid and …

Background Pharmacokinetic (PK) and pharmacodynamic (PD) models are used in target-
controlled-infusion (TCI) systems to determine the optimal drug administration to achieve a …

BACKGROUND: Pharmacokinetic (PK) models are used to predict drug concentrations for
infusion regimens for intraoperative displays and to calculate infusion rates in target …

BACKGROUND: The unique anesthetic risks associated with the morbidly obese (MO)
population have been documented. Pharmacologic management of these patients may be …

BACKGROUND: With the growing use of pharmacokinetic (PK)-driven drug delivery and/or
drug advisory displays, identifying the PK model that best characterizes propofol plasma …

Remimazolam, a short‐acting benzodiazepine, may be used for induction and maintenance
of total intravenous anaesthesia, but its role in the management of patients with multiple …

BACKGROUND:: The SEDASYS System is an investigational computer-assisted
personalized sedation system integrating propofol delivery with patient monitoring to enable …

BACKGROUND: Obesity is associated with important physiologic changes that can
potentially affect the pharmacokinetic (PK) and pharmacodynamic (PD) profile of anesthetic …

Objectives: The authors sought to compare the safety and efficacy of subdissociative‐dose
ketamine versus fentanyl as adjunct analgesics for emergency department (ED) procedural …