Vitamin A and its derivatives, retinoids, have been widely studied for their use as cancer
chemotherapeutic agents. With respect to colorectal cancer (CRC), several critical mutations …

Inflammation is the body's response to cell damage. Cancer is a general term that describes
all malignant tumours. There are no confirmed data on cancer-related inflammation, but …

Gastric carcinoma is one of the most common cancers and lethal malignancies worldwide.
Thus far, the regulatory mechanisms of its aggressiveness are still poorly understood. To …

Abstract Background Cyclooxygenase-2 (COX-2, PTGS2) is an enzyme involved in the
synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes …

MicroRNAs are strongly implicated in cancer but their specific roles and functions in the
major cancers have yet to be fully elucidated. In this study, we defined the expression and …

Background: Colorectal carcinoma (CRC) is the most common neoplasm of the
gastrointestinal tract. COX-2 plays an important role in CRC development and is a key target …

Gastric carcinoma is one of the most common and mortal types of malignancy worldwide. To
date, the mechanisms controlling its aggressiveness are not yet fully understood. Notch …

Pancreatic cancer is one of the most lethal human cancers, with almost identical incidence
and mortality rates. Curcumin, derived from the rhizome of Curcuma longa, has a long …

Abstract Overexpression of Cyclooxygenase‐2 (COX‐2) is observed in most tumor types.
Increased COX‐2 activity and synthesis of prostaglandins stimulates proliferation …

Arachidonic acid metabolism through cyclooxygenase (COX) pathways leads to the
generation of biologically active eicosanoids. Eicosanoid expression levels vary during …