Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective
The airways of patients with cystic fibrosis (CF) are nearly always infected with many
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …
different microorganisms. This environment offers warm, humid and nutrient-rich conditions …
Acyl-homoserine lactone quorum sensing: from evolution to application
M Schuster, D Joseph Sexton, SP Diggle… - Annual review of …, 2013 - annualreviews.org
Quorum sensing (QS) is a widespread process in bacteria that employs autoinducing
chemical signals to coordinate diverse, often cooperative activities such as …
chemical signals to coordinate diverse, often cooperative activities such as …
The distribution of bacterial doubling times in the wild
Generation time varies widely across organisms and is an important factor in the life cycle,
life history and evolution of organisms. Although the doubling time (DT) has been estimated …
life history and evolution of organisms. Although the doubling time (DT) has been estimated …
The role of bacterial biofilms in chronic infections
T Bjarnsholt - Apmis, 2013 - Wiley Online Library
Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …
100 years. These infections killed millions of people in previous centuries, but they have …
A Pseudomonas aeruginosa small RNA regulates chronic and acute infection
The ability to switch between different lifestyles allows bacterial pathogens to thrive in
diverse ecological niches,. However, a molecular understanding of their lifestyle changes …
diverse ecological niches,. However, a molecular understanding of their lifestyle changes …
Requirements for Pseudomonas aeruginosa Acute Burn and Chronic Surgical Wound Infection
Opportunistic infections caused by Pseudomonas aeruginosa can be acute or chronic. While
acute infections often spread rapidly and can cause tissue damage and sepsis with high …
acute infections often spread rapidly and can cause tissue damage and sepsis with high …
Cystic fibrosis: a mucosal immunodeficiency syndrome
TS Cohen, A Prince - Nature medicine, 2012 - nature.com
Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that
regulates the transport of ions and the movement of water across the epithelial barrier …
regulates the transport of ions and the movement of water across the epithelial barrier …
Bacterial quorum sensing and microbial community interactions
Many bacteria use a cell-cell communication system called quorum sensing to coordinate
population density-dependent changes in behavior. Quorum sensing involves production of …
population density-dependent changes in behavior. Quorum sensing involves production of …
Regional isolation drives bacterial diversification within cystic fibrosis lungs
Bacterial lineages that chronically infect cystic fibrosis (CF) patients genetically diversify
during infection. However, the mechanisms driving diversification are unknown. By …
during infection. However, the mechanisms driving diversification are unknown. By …
Clinical significance of microbial infection and adaptation in cystic fibrosis
AR Hauser, M Jain, M Bar-Meir… - Clinical microbiology …, 2011 - Am Soc Microbiol
SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …
fibrosis. Once established within the pulmonary environment in these patients, many of …