BACKGROUND Primary ovarian insufficiency (POI) is characterized by marked
heterogeneity, but with a significant genetic contribution. Identifying exact causative genes …

Menopause is the final step in the process referred to as ovarian ageing. The age related
decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of …

Premature ovarian insufficiency (POI) is one form of female infertility, defined by loss of
ovarian activity before the age of 40 and characterized by amenorrhea (primary or …

Human Blepharophimosis/ptosis/epicanthus inversus syndrome (BPES) type I is an
autosomal dominant disorder associated with premature ovarian failure (POF) caused by …

In type I blepharophimosis/ptosis/epicanthus inversus syndrome (BPES), eyelid
abnormalities are associated with ovarian failure. Type II BPES shows only the eyelid …

Premature ovarian failure (POF) causing hypergonadotrophic hypogonadism occurs in 1%
of women. In majority of cases the underlying cause is not identified. The known causes …

FOXL2 mutations cause gonadal dysgenesis or premature ovarian failure (POF) in women,
as well as eyelid/forehead dysmorphology in both sexes (the 'blepharophimosis–ptosis …

The world's population is increasing at an alarming rate and is projected to reach nine billion
by 2050. Despite this, 15% of couples world-wide remain childless because of infertility. Few …

Hypergonadotropic ovarian failure is a common cause of female infertility. It is a
heterogeneous disorder that, in the most severe forms, is a result of ovarian dysgenesis …

Premature ovarian failure (POF) is a primary ovarian defect characterized by absent
menarche (primary amenorrhea) or premature depletion of ovarian follicles before the age of …