Cognitive decline in Parkinson disease

D Aarsland, B Creese, M Politis… - Nature Reviews …, 2017 - nature.com
Dementia is a frequent problem encountered in advanced stages of Parkinson disease (PD).
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …

Long-term outcomes of deep brain stimulation in Parkinson disease

P Limousin, T Foltynie - Nature Reviews Neurology, 2019 - nature.com
The efficacy of deep brain stimulation (DBS) for Parkinson disease (PD) is well established
for up to 1 or 2 years, but long-term outcome data are still limited. In this Review, we critically …

Parkinson's disease dementia: a neural networks perspective

J Gratwicke, M Jahanshahi, T Foltynie - Brain, 2015 - academic.oup.com
In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

Cognition deficits in Parkinson's disease: mechanisms and treatment

C Fang, L Lv, S Mao, H Dong, B Liu - Parkinson's disease, 2020 - Wiley Online Library
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disorder mainly in middle‐elderly population, which represents diverse nonmotor symptoms …

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease

AKL Liu, RCC Chang, RKB Pearce… - Acta neuropathologica, 2015 - Springer
It has been well established that neuronal loss within the cholinergic nucleus basalis of
Meynert (nbM) correlates with cognitive decline in dementing disorders such as Alzheimer's …

Lewy body disease or diseases with Lewy bodies?

K Menšíková, R Matěj, C Colosimo, R Rosales… - npj Parkinson's …, 2022 - nature.com
The current nosological concept of α-synucleinopathies characterized by the presence of
Lewy bodies (LBs) includes Parkinson's disease (PD), Parkinson's disease dementia (PDD) …

In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo Parkinson's disease

NJ Ray, S Bradburn, C Murgatroyd, U Toseeb, P Mir… - Brain, 2018 - academic.oup.com
Abstract See Gratwicke and Foltynie (doi: 10.1093/brain/awx333) for a scientific commentary
on this article. Cognitive impairments are a prevalent and disabling non-motor complication …

[PDF][PDF] Modulation of human memory by deep brain stimulation of the entorhinal-hippocampal circuitry

EA Mankin, I Fried - Neuron, 2020 - cell.com
Neurological disorders affecting human memory present a major scientific, medical, and
societal challenge. Direct or indirect deep brain stimulation (DBS) of the entorhinal …

[HTML][HTML] Brain stimulation in Alzheimer's disease

CH Chang, HY Lane, CH Lin - Frontiers in psychiatry, 2018 - frontiersin.org
Brain stimulation techniques can modulate cognitive functions in many neuropsychiatric
diseases. Pilot studies have shown promising effects of brain stimulations on Alzheimer's …

Behavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines

D Puzzo, L Lee, A Palmeri, G Calabrese… - Biochemical …, 2014 - Elsevier
In Alzheimer's disease (AD) basic research and drug discovery, mouse models are essential
resources for uncovering biological mechanisms, validating molecular targets and screening …