[HTML][HTML] Therapeutic potential of pyrrole and pyrrolidine analogs: an update

N Jeelan Basha, SM Basavarajaiah, K Shyamsunder - Molecular Diversity, 2022 - Springer
The chemistry of nitrogen-containing heterocyclic compound pyrrole and pyrrolidine has
been a versatile field of study for a long time for its diverse biological and medicinal …

The Multi‐Pharmacological Targeted Role of Indole and its Derivatives: A review

B Suliphuldevara Mathada… - …, 2023 - Wiley Online Library
Heterocycles are a privileged motif that appears as a momentous objective in medicinal
chemistry. An important class of compounds for drug discovery and design is indole and its …

The versatile quinoline and its derivatives as anti-cancer agents: an overview

BS Mathada - Polycyclic Aromatic Compounds, 2023 - Taylor & Francis
Quinoline heterocycles have been considered important structures due to their diverse
applications in organic synthesis, coordination chemistry, as well as in the fields of drug …

Naphtho [2, 1-b] furan derived triazole-pyrimidines as highly potential InhA and Cytochrome c peroxidase inhibitors: Synthesis, DFT calculations, drug-likeness profile …

DL Roopa, K Shyamsunder, P Karunakar… - Journal of Molecular …, 2023 - Elsevier
Napthofuran and its fused heterocyclic derivatives evaluated with varied biological activity
functional groups comprise an important class of compounds for new chemical entities. We …

Design, Spectral analysis, DFT calculations, antimicrobial, anti-TB, antioxidant activity and molecular docking studies of novel bis-benzoxazines with cytochrome c …

GY Nagesh, M Javeed, JN Basha, K Prashantha… - Journal of Molecular …, 2022 - Elsevier
We herein report the efficient synthesis of symmetrical bis-benzoxazines by substituted
salicylaldehydes and alkyl diamines. The substituted salicylaldehydes (1a-d) and alkyl …

Novel pyrimidines as COX-2 selective inhibitors: synthesis, DFT analysis, molecular docking and dynamic simulation studies

BS Mathada, NJ Basha, M Javeed… - Journal of …, 2024 - Taylor & Francis
Pyrimidine and its derivatives are associated with varieties of biological properties.
Therefore, we herein reported the synthesis of four novel pyrimidines (2, 3, and 4a, b) …

Exploration of Indolo [3, 2c] isoquinoline derived triazoles as potential antimicrobial and DNA cleavage agents: Synthesis, DFT calculations, and molecular modeling …

SM Basavarajaiah, J Badiger, NG Yernale, N Gupta… - Bioorganic …, 2023 - Elsevier
Indole and its derivatives are well-known assorted motif in drug design and development.
We here in reporting synthesis of new 9-chloro-1-(4-substituted phenyl)-12H-indolo [2, 3 …

Indole frameworks via transition-metal-free annulation: a current perspective

S Das - New Journal of Chemistry, 2023 - pubs.rsc.org
Indole structural motifs are ubiquitous in natural products, pharmaceuticals, agrochemicals
and functional materials. The immense importance of indole moiety, especially in the field of …

Synthesis, spectral analysis, DFT calculations, biological potential and molecular docking studies of indole appended pyrazolo-triazine

SM Basavarajaiah, GY Nagesh, M Javeed, R Bhat… - Molecular Diversity, 2023 - Springer
Abstract A series of novel 5-(3, 5-disubstituted-1 H-indol-2-yl)-2, 3-dimethyl-1-phenyl-2, 6-
dihydro-1 H-pyrazolo [4, 3-e][1, 2, 4] triazines (3a-l) were synthesized in single step from 3, 5 …

Spectroscopic, theoretical and computational investigations of novel benzo [b] thiophene based ligand and its M (II) complexes: As high portentous antimicrobial and …

NG Yernale, BS Mathada, S Shivprasad… - … Acta Part A: Molecular …, 2023 - Elsevier
The reaction of 3-chlorobenzo [b] thiophene-2-carbohydrazide with 4-(diethylamino)
salicylaldehyde gave the new ligand; 3-chloro-N'-(4-(diethylamino)-2-hydroxybenzylidene) …