Abstract Background The Infectious Diseases Society of America is committed to providing
up-to-date guidance on the treatment of antimicrobial-resistant infections. This guidance …

Infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-
negative bacteria (GNB), including carbapenem-resistant (CR) Enterobacterales (CRE; …

The spread of Enterobacteriaceae, primarily Klebsiella pneumoniae, producing KPC, VIM,
IMP, and NDM carbapenemases, is causing an unprecedented public health crisis …

Hospital-acquired infections are most commonly associated with mechanical ventilation,
invasive medical devices, or surgical procedures. Gram-negative bacteria are responsible …

Acinetobacter baumannii has emerged as a highly troublesome pathogen for many
institutions globally. As a consequence of its immense ability to acquire or upregulate …

Objective: To discuss the altered pharmacokinetic properties of selected antibiotics in
critically ill patients and to develop basic dose adjustment principles for this patient …

Introduction Several reports have shown marked heterogeneity of antibiotic
pharmacokinetics (PK) in patients admitted to ICUs, which might potentially affect outcomes …

Acinetobacter baumannii remains an important and difficult-to-treat pathogen whose
resistance patterns result in significant challenges for the clinician. Despite the prevalence …

Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient
serum β-lactam concentrations when standard dosages are administered. Previous studies …

We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD)
properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is …