Severe sepsis and septic shock are a major challenge for critical care clinicians because of
the associated high rates of morbidity and mortality. In the United States, the estimated …

The objectives of this study were to develop a meropenem population pharmacokinetic
model using patient data and use it to explore alternative dosage regimens that could …

Continuous infusion of β-lactam antibiotics has been widely promoted to optimise their time-
dependent activity. Increasing evidence is emerging suggesting potential benefits in patient …

Patients admitted to Intensive Care Units (ICUs) are at very high risk of developing severe
nosocomial infections. Consequently, antimicrobials are among the most important and …

Background Intravenous broad–spectrum antibiotics are indicated for the treatment of
severe infections. However, the emergence of infections caused by multiple‐drug resistant …

ABSTRACT A patient with septic shock due to extensively drug resistant (XDR)
Pseudomonas aeruginosa was cured by optimizing the meropenem (MEM) regimen to …

There is controversy over whether traditional intermittent bolus dosing or continuous infusion
of beta-lactam antibiotics is preferable in critically ill patients. No significant difference …

ABSTRACT A population pharmacokinetic model of cefepime was constructed from data
from adult critical care patients with ventilator-associated pneumonia (VAP). A total of 32 …

The A. baumannii-calcoaceticus complex continues to play a significant role in our
healthcare systems. Prompt and adequate therapy with agents having in-vitro activity is …

Objectives The objective of this study was to propose an optimal treatment regimen of
meropenem in critically ill patients with severe nosocomial pneumonia. Patients and …