Infections and related sepsis are two of the most prevalent issues in the care of critically ill
patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate …

Background Optimal anti-bacterial activity of meropenem requires maintenance of its plasma
concentration (Cp) above the minimum inhibitory concentration (MIC) of the pathogen for at …

Combination therapy provides a useful therapeutic approach to overcome resistance until
new antibiotics become available. In this study, the pharmacodynamics, including the …

Intravenous (IV) push administration can provide clinical and practical advantages over
longer IV infusions in multiple clinical scenarios, including in the emergency department, in …

Consolidated data from pharmacokinetic and pharmacodynamic studies support the
administration of β-lactam antibiotics in prolonged infusion (ie, extended or continuous) to …

Objective Extreme drug-resistant Pseudomonas aeruginosa (XDR-PA) with decreased
susceptibility to polymyxin B (PB) has emerged in Singapore, causing infections in …

Available therapeutic options against carbapenem-resistant Klebsiella pneumoniae (CR-Kp)
are limited because of the high level of resistance to other antimicrobial classes including …

Objectives Broad-spectrum antimicrobial resistance in Pseudomonas aeruginosa (PSA)
isolates is a growing concern as our therapeutic options have become significantly limited …

Background The primary objective of this meta-analysis is aimed at determining whether β-
lactams prolonged infusion in patients with nosocomial pneumonia (NP) results in higher …

Gram-negative bacterial pathogens are a common cause of infection, and the prevalence
and rates of resistance among these pathogens to existing antimicrobial agents are …