The alarming global rise of antimicrobial resistance combined with the lack of new
antimicrobial agents has led to a renewed interest in optimization of our current antibiotics …

Introduction The aim of this study was to determine whether using pharmacodynamic-based
dosing of antimicrobials, such as extended/continuous infusions, in critically ill patients is …

Acinetobacter is a formidable challenge to managing critically ill patients. This pathogen's
ability to rapidly develop antimicrobial resistance to all currently available antimicrobial …

Safe and effective therapies are urgently needed to treat polymyxin-resistant KPC-producing
Klebsiella pneumoniae infections and suppress the emergence of resistance. We …

The growing number of infections caused by multidrug-resistant pathogens has prompted a
more rational use of available antibiotics given the paucity of new, effective agents. Monte …

To investigate the correlation between carbapenem consumption and rates of antimicrobial
resistance in Acinetobacter baumannii, carbapenem consumption was expressed as …

Background Limited knowledge of the local molecular epidemiology and the paucity of new
effective antibiotics has resulted in an immense challenge in the control and treatment of …

Development and validation of large animal models of Pseudomonas aeruginosa ventilator-
associated pneumonia are needed for testing new drug candidates in a manner that mimics …

This study aimed to describe the pharmacokinetic (PK) characteristics of meropenem in
children with severe infections and to assess the pharmacokinetic/pharmacodynamic …

The bactericidal activity of β-lactams is determined by the time that concentrations in tissue
and serum are above the minimum inhibitory concentration (T> MIC) for the pathogen. The …