Background: Pharmacokinetics of meropenem differ widely in the critically ill population. It is
imperative to maintain meropenem concentrations above the inhibitory concentrations for …

The study objective was to evaluate meropenem pharmacokinetics and pharmacodynamics
in morbid obesity. Nine patients hospitalized in an intensive care unit with a body mass …

Nosocomial pneumonia (including ventilator-associated pneumonia; VAP), a consistently
difficult-to-treat entity, is frequently caused by multidrug-resistant (MDR) or pandrug-resistant …

Objective: To systematically review evidence comparing traditional and alternative dosing
strategies for meropenem, based on clinical and pharmacoeconomic outcomes. Data …

Aim: Efficacy of colistin and ampicillin–sulbactam have not been compared in treatment of
ventilator-associated pneumonia due to A. baumannii. Efficacy of colistin and ampicillin …

Treatment of infections with carbapenem-resistant Gram negative organism is a major
challenge especially among intensive care patients. Combinations of sulbactam …

Objectives The aim of this study was to compare the t> MICs of imipenem between
administration by a 2 h infusion with a 0.5 h infusion. Methods The study was a randomized …

Mounting antimicrobial resistance to carbapenemase‐producing Klebsiella pneumoniae
(CPKP) highlights the need to optimize currently available treatment options. The objective …

Given that tigecycline-based combination therapy is recognized as a valuable option for the
treatment of tigecycline-resistant Acinetobacter baumannii, we conducted this systematic …