Meropenem Stability in Human Plasma at− 20° C: Detailed Assessment of Degradation
There are concerns about the stability of meropenem in plasma samples, even when frozen
at− 20° C. Previous smaller studies suggested significant degradation of meropenem at …
at− 20° C. Previous smaller studies suggested significant degradation of meropenem at …
Evaluation of Meropenem Regimens Suppressing Emergence of Resistance in Acinetobacter baumannii with Human Simulated Exposure in an In Vitro Intravenous …
X Li, L Wang, XJ Zhang, Y Yang, WT Gong… - Antimicrobial agents …, 2014 - Am Soc Microbiol
The emergence of resistance to carbapenems in Pseudomonas aeruginosa can be
suppressed by optimizing the administration of meropenem. However, whether the same is …
suppressed by optimizing the administration of meropenem. However, whether the same is …
Appropriate antibiotic dosage levels in the treatment of severe sepsis and septic shock
FS Taccone, M Hites, M Beumier, S Scolletta… - Current infectious …, 2011 - Springer
Antibiotic treatment of critically ill patients remains a significant challenge. Optimal
antibacterial strategy should achieve therapeutic drug concentration in the blood as well as …
antibacterial strategy should achieve therapeutic drug concentration in the blood as well as …
The new treatment paradigm and the role of carbapenems
RG Masterton - International Journal of Antimicrobial Agents, 2009 - Elsevier
The global increase in antibiotic resistance is promoted by the widespread use of broad-
spectrum antibiotics, creating a continuous selective pressure on bacteria. This resistance is …
spectrum antibiotics, creating a continuous selective pressure on bacteria. This resistance is …
Carbapenems for the treatment of immunocompetent adult patients with nosocomial pneumonia
II Siempos, KZ Vardakas, KG Manta… - European Respiratory …, 2007 - Eur Respiratory Soc
The comparative effectiveness and safety of carbapenems with other β-lactams and
fluoroquinolones for the empirical treatment of patients with hospital-acquired pneumonia …
fluoroquinolones for the empirical treatment of patients with hospital-acquired pneumonia …
Dose optimization of colistin combinations against carbapenem-resistant Acinetobacter baumannii from patients with hospital-acquired pneumonia in China by using …
X Bian, X Liu, Y Chen, D Chen, J Li… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
Colistin-based combination therapy has become an important strategy to combat the
carbapenem-resistant Acinetobacter baumannii (CRAB). However, the optimal dosage …
carbapenem-resistant Acinetobacter baumannii (CRAB). However, the optimal dosage …
Comparison of short versus prolonged infusion of standard dose of meropenem against carbapenemase-producing Klebsiella pneumoniae isolates in different patient …
Dose optimization is required to increase carbapenem's efficacy against carbapenemase-
producing isolates. Four clinical Klebsiella pneumoniae isolates were used: one susceptible …
producing isolates. Four clinical Klebsiella pneumoniae isolates were used: one susceptible …
Population pharmacokinetics/pharmacodynamics and clinical outcomes of meropenem in critically ill patients
A Boonpeng, S Jaruratanasirikul… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Several pathophysiological changes can alter meropenem pharmacokinetics in critically ill
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …
patients, thereby increasing the risk of subtherapeutic concentrations and affecting …
In vitro activity of apramycin (EBL-1003) in combination with colistin, meropenem, minocycline or sulbactam against XDR/PDR Acinetobacter baumannii isolates from …
Objectives To evaluate the in vitro activity of the combination of apramycin with colistin,
meropenem, minocycline or sulbactam, against some well-characterized XDR Acinetobacter …
meropenem, minocycline or sulbactam, against some well-characterized XDR Acinetobacter …