Purpose This study aimed to investigate the pharmacokinetics and target attainment of
meropenem and compare the effect of meropenem dosing regimens in critically ill patients …

Against extensively drug-resistant (XDR) Enterobacter cloacae, combination antibiotic
therapy may be the only option. We investigated the activity of various antibiotics in …

Infections are a major problem in patients with burn diseases. Mortality is high despite
antibiotic therapy as studies are controversial concerning drug underdosing. The aims of this …

Antipseudomonal carbapenems have played a useful role in our antimicrobial
armamentarium for 20 years. However, a review of their use during that period creates …

In this study we compared the efficacy of a theoretically optimized two-step infusion therapy
(OTIT; rapid first-step infusion and slow second-step infusion) to the efficacies of prolonged …

Carbapenems are the most potent group of beta-lactam agents, having a broad spectrum of
bactericidal activity against both Gram-negative and Gram-positive bacteria including …

Polymyxin B-based combinations have emerged as a mainstay treatment against
carbapenem-resistant Escherichia coli (CREC). We investigated the activity of polymyxin B …

Introduction Combination therapy is increasingly utilized against extensively-drug resistant
(XDR) Gram negative bacteria (GNB). However, choosing a combination can be problematic …

Objective: To test whether a prolonged 3-hour infusion of meropenem 500mg achieves an
equivalent proportion of time above the minimal inhibitory concentration (MIC)(% T MIC) to …