Abstract Alpha-1-Antitrypsin deficiency (AATD), caused by SERPINA1 mutations, is one of
the most prevalent Mendelian disorders among individuals of European descend. However …

We review studies from our laboratories using different molecular tools to characterize the
Amerindian, European and African ancestry of Brazilians. Initially we used uniparental DNA …

Brazil is experiencing among the world's fastest demographic aging worldwide. This
demographic transition is occurring in a context of few resources and great social …

Brazilians are highly admixed with ancestry from Europe, Africa, America, and Asia and yet
still underrepresented in genomic databanks. We hereby present a collection of exomic …

South America has a complex demographic history shaped by multiple migration and
admixture events in pre-and post-colonial times. Settled over 14,000 years ago by Native …

The Out-of-Africa (OOA) dispersal∼ 50,000 y ago is characterized by a series of founder
events as modern humans expanded into multiple continents. Population genetics theory …

As whole-genome sequencing (WGS) becomes the gold standard tool for studying
population genomics and medical applications, data on diverse non-European and admixed …

Context: Central precocious puberty (CPP) results from premature activation of the
hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with …

Historical records and genetic analyses indicate that Latin Americans trace their ancestry
mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan …

Abstract The African Diaspora in the Western Hemisphere represents one of the largest
forced migrations in history and had a profound impact on genetic diversity in modern …