Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

From the earliest comparisons of RNA production with steady-state levels, it has been clear
that cells transcribe more RNA than they accumulate, implying the existence of active RNA …

The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic
phosphorylation during transcription, and the different phosphorylation patterns that …

Increasing evidence has demonstrated that small nucleolar RNAs (snoRNAs) play important
roles in tumorigenesis. We systematically investigated the expression landscape and clinical …

Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

Drosophila contains one (dCDK12) and humans contain two (hCDK12 and hCDK13)
proteins that are the closest evolutionary relatives of yeast Ctk1, the catalytic subunit of the …