Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose

C Doyno, DM Sobieraj, WL Baker - Clinical Toxicology, 2021 - Taylor & Francis
Introduction While chloroquine, a derivative of quinine, has been used as an antimalarial for
70 years, hydroxychloroquine is now used to treat conditions such as rheumatoid arthritis …

COVID-19: therapeutics and their toxicities

MA Chary, AF Barbuto, S Izadmehr, BD Hayes… - Journal of Medical …, 2020 - Springer
SARS-CoV-2 is a novel coronavirus that emerged in 2019 and is causing the COVID-19
pandemic. There is no current standard of care. Clinicians need to be mindful of the toxicity …

Acute chloroquine and hydroxychloroquine toxicity: a review for emergency clinicians

A Della Porta, K Bornstein, A Coye, T Montrief… - The American journal of …, 2020 - Elsevier
Background Acute chloroquine and hydroxychloroquine toxicity is characterized by a
combination of direct cardiovascular effects and electrolyte derangements with resultant …

Clinical efficacy of chloroquine derivatives in COVID-19 infection: comparative meta-analysis between the big data and the real world

M Million, P Gautret, P Colson, Y Roussel… - New Microbes and New …, 2020 - Elsevier
In the context of the current coronavirus disease 2019 (COVID-19) pandemic, we conducted
a meta-analysis on the effects of chloroquine derivatives in patients, based on unpublished …

Ultrasonic-assisted fabrication of MIL-100 (Fe) metal–organic frameworks as a carrier for the controlled delivery of the chloroquine drug

BT Le, DD La, PTH Nguyen - ACS omega, 2022 - ACS Publications
Metal–organic framework materials (MOFs) are materials with an ordered crystalline
structure and high porosity that have been intensively investigated for many applications …

[HTML][HTML] Diagnostic pitfalls and laboratory test interference after hydroxychloroquine intoxication: A case report

JB Radke, JM Kingery, J Maakestad, MD Krasowski - Toxicology reports, 2019 - Elsevier
Hydroxychloroquine is a medication used to treat autoimmune conditions. Overdoses of
hydroxychloroquine are uncommon, with most recommendations on monitoring drawing …

Development, validation and clinical application of a LC-MS/MS method for the simultaneous quantification of hydroxychloroquine and its active metabolites in human …

M Soichot, B Mégarbane, P Houzé, L Chevillard… - … of pharmaceutical and …, 2014 - Elsevier
A rapid, sensitive and specific method using liquid chromatography coupled to tandem mass
spectrometry was developed for the simultaneous quantification of hydroxychloroquine …

Hydroxychloroquine does not increase the risk of cardiac arrhythmia in common rheumatic diseases: a nationwide population-based cohort study

CH Lo, JCC Wei, YH Wang, CF Tsai, KC Chan… - Frontiers in …, 2021 - frontiersin.org
Objectives Hydroxychloroquine (HCQ) is widely used to treat rheumatic diseases including
rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and Sjögren's syndrome …

Cardiac complications attributed to hydroxychloroquine: a systematic review of the literature pre-COVID-19

G Fram, DD Wang, K Malette… - Current Cardiology …, 2021 - ingentaconnect.com
Introduction: Hydroxychloroquine has been used for rheumatological diseases for many
decades and is considered a safe medication. With the COVID-19 outbreak, there has been …

Survival after massive hydroxychloroquine overdose

N Gunja, D Roberts, D McCoubrie… - … and intensive care, 2009 - journals.sagepub.com
Hydroxychloroquine overdose is infrequently reported and the majority of recommendations
come from the greater experience with chloroquine poisoning. We report two cases of …