Mathematical modeling clarifies the paracrine roles of insulin and glucagon on the glucose-stimulated hormonal secretion of pancreatic alpha-and beta-cells
A Brown, ES Tzanakakis - Frontiers in Endocrinology, 2023 - frontiersin.org
Introduction Blood sugar homeostasis relies largely on the action of pancreatic islet
hormones, particularly insulin and glucagon. In a prototypical fashion, glucagon is released …
hormones, particularly insulin and glucagon. In a prototypical fashion, glucagon is released …
Characterisation of cotadutide's dual GLP‐1/glucagon receptor agonistic effects on glycaemic control using an in vivo human glucose regulation quantitative systems …
R Bosch, M Petrone, R Arends, P Vicini… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Cotadutide is a dual GLP‐1 and glucagon receptor
agonist with balanced agonistic activity at each receptor designed to harness the …
agonist with balanced agonistic activity at each receptor designed to harness the …
Quantification of the effect of GLP‐1R agonists on body weight using in vitro efficacy information: An extension of the Hall body composition model
R Bosch, EJG Sijbrands… - CPT: Pharmacometrics & …, 2024 - Wiley Online Library
Obesity has become a major public health concern worldwide. Pharmacological
interventions with the glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have shown …
interventions with the glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have shown …
Population Approach Group Europe Population Approach Group Europe
M Block - page-meeting.org
Objectives: MEDI0382 is a synthetic peptide with both glucagon-like peptide-1 (GLP-1) and
glucagon receptor co-agonist activity. The combination of GLP-1 and glucagon activity has …
glucagon receptor co-agonist activity. The combination of GLP-1 and glucagon activity has …