[HTML][HTML] Hemorheological and microcirculatory factors in liver ischemia-reperfusion injury—An update on pathophysiology, molecular mechanisms and protective …

N Nemeth, K Peto, Z Magyar, Z Klarik, G Varga… - International journal of …, 2021 - mdpi.com
Hepatic ischemia-reperfusion injury (IRI) is a multifactorial phenomenon which has been
associated with adverse clinical outcomes. IRI related tissue damage is characterized by …

[HTML][HTML] Renal delivery of pharmacologic agents during machine perfusion to prevent ischaemia-reperfusion injury: from murine model to clinical trials

R Franzin, A Stasi, M Fiorentino, S Simone… - Frontiers in …, 2021 - frontiersin.org
Donor organ shortage still remains a serious obstacle for the access of wait-list patients to
kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand …

[HTML][HTML] Molecular markers of kidney transplantation outcome: current omics tools and future developments

M Lepoittevin, T Kerforne, L Pellerin, T Hauet… - International Journal of …, 2022 - mdpi.com
Purpose of review: The emerging field of molecular predictive medicine is aiming to change
the traditional medical approach in renal transplantation. Many studies have explored …

[HTML][HTML] Assessment of oxidative stress markers in hypothermic preservation of transplanted kidneys

K Tejchman, A Sierocka, K Kotfis, M Kotowski… - Antioxidants, 2021 - mdpi.com
Ischemia-reperfusion injury (IRI) after renal transplantation is a complex biochemical
process. The first component is an ischemic phase during kidney storage. The second is …

[HTML][HTML] Solid Phase Microextraction—A Promising Tool for Graft Quality Monitoring in Solid Organ Transplantation

K Łuczykowski, N Warmuzińska, B Bojko - Separations, 2023 - mdpi.com
Solid organ transplantation is a life-saving intervention for patients suffering from end-stage
organ failure. Although improvements in surgical techniques, standards of care, and …

Metabolomic and lipidomic landscape of porcine kidney associated with kidney perfusion in heart beating donors and donors after cardiac death

I Stryjak, N Warmuzińska, K Łuczykowski, K Jaroch… - Translational …, 2024 - Elsevier
Transplant centers are currently facing a lack of tools to ensure adequate evaluation of the
quality of the available organs, as well as a significant shortage of kidney donors. Therefore …

[HTML][HTML] The role of endothelins, IL-18, and NGAL in kidney hypothermic machine perfusion

K Tejchman, A Nowacki, K Kotfis, E Skwirczynska… - Biomedicines, 2021 - mdpi.com
Ischemia-reperfusion injury (IRI) occurring after renal transplantation is a complex
biochemical process that can be monitored by specific biomarkers. The roles of those are …

[HTML][HTML] Subnormothermic ex vivo lung perfusion possibly protects against ischemia-reperfusion injury via the mTORC-HIF-1α pathway

JW Suh, SJ Park, YW Koh, D Seo… - Journal of Thoracic …, 2024 - ncbi.nlm.nih.gov
Background Ex vivo lung perfusion (EVLP) is a useful technique for evaluating and repairing
donor lungs for transplantation. However, studies examining the effects of perfusate …

[HTML][HTML] Metabolomics Differences of the Donor Livers Between In Situ and Ex Situ Conditions During Ischemia-free Liver Transplantation

Z Guo, L Zhan, N Gao, Z Zhang, S Huang… - …, 2023 - journals.lww.com
Background. Ischemia-free liver transplantation (IFLT) has been innovated to avoid graft
ischemia during organ procurement, preservation, and implantation. However, the …

[HTML][HTML] Perfusate metabolomics content and expression of tubular transporters during human kidney graft preservation by hypothermic machine perfusion

Q Faucher, H Alarcan, FL Sauvage, L Forestier… - …, 2022 - journals.lww.com
Background. Ischemia-related injury during the preimplantation period impacts kidney graft
outcome. Evaluating these lesions by a noninvasive approach before transplantation could …