Comorbidities and the impact of atopic dermatitis

JI Silverberg - Annals of Allergy, Asthma & Immunology, 2019 - Elsevier
Objective Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease with
substantial patient and population burdens. A number of comorbid health problems occur in …

Selective JAK1 inhibitors for the treatment of atopic dermatitis: focus on upadacitinib and abrocitinib

S Ferreira, E Guttman-Yassky, T Torres - American journal of clinical …, 2020 - Springer
Atopic dermatitis is a common, chronic, immune-mediated disease associated with several
comorbidities. Elevated levels of T helper (Th) 2, Th22, and also some Th1 and Th17 …

European guideline (EuroGuiDerm) on atopic eczema–part II: non‐systemic treatments and treatment recommendations for special AE patient populations

A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …

Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised …

EL Simpson, R Sinclair, S Forman, A Wollenberg… - The Lancet, 2020 - thelancet.com
Background Abrocitinib, an oral selective Janus kinase 1 inhibitor, was effective and well
tolerated in adults with moderate-to-severe atopic dermatitis in a phase 2b trial. We aimed to …

Efficacy and safety of abrocitinib in patients with moderate-to-severe atopic dermatitis: a randomized clinical trial

JI Silverberg, EL Simpson, JP Thyssen… - JAMA …, 2020 - jamanetwork.com
Importance Abrocitinib, an oral, once-daily Janus kinase 1 selective inhibitor, was effective
and well tolerated in a phase 3 monotherapy trial of patients with moderate-to-severe atopic …

American Academy of Dermatology Guidelines: awareness of comorbidities associated with atopic dermatitis in adults

DMR Davis, AM Drucker, A Alikhan, L Bercovitch… - Journal of the American …, 2022 - Elsevier
Background Studies found associations between atopic dermatitis (AD) and various
comorbidities. Objective To appraise evidence of the association between AD and …

[HTML][HTML] Upadacitinib plus topical corticosteroids in atopic dermatitis: Week 52 AD Up study results

JI Silverberg, M de Bruin-Weller, T Bieber… - Journal of Allergy and …, 2022 - Elsevier
Background Primary (week 16) results from the ongoing phase 3, double-blind AD Up study
(NCT03568318) demonstrate a positive benefit–risk profile for upadacitinib+ topical …

Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two …

E Guttman-Yassky, HD Teixeira, EL Simpson, KA Papp… - The Lancet, 2021 - thelancet.com
Background Upadacitinib is an oral Janus kinase (JAK) inhibitor with greater inhibitory
potency for JAK1 than JAK2, JAK3, and tyrosine kinase 2. We aimed to assess the efficacy …

[HTML][HTML] Comorbidities of atopic dermatitis—what does the evidence say?

JP Thyssen, AS Halling, P Schmid-Grendelmeier… - Journal of Allergy and …, 2023 - Elsevier
Atopic dermatitis (AD) is a common disease that is associated with atopic and nonatopic
comorbidities. There has been a growing interest in this area of AD, because presence or …

Skin care interventions in infants for preventing eczema and food allergy

MM Kelleher, R Phillips, SJ Brown… - Cochrane Database …, 2022 - cochranelibrary.com
Background Eczema and food allergy are common health conditions that usually begin in
early childhood and often occur in the same people. They can be associated with an …