Copper homeostasis and cuproptosis in health and disease

L Chen, J Min, F Wang - Signal transduction and targeted therapy, 2022 - nature.com
As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Mitochondria-associated programmed cell death as a therapeutic target for age-related disease

TT Nguyen, S Wei, TH Nguyen, Y Jo, Y Zhang… - … & Molecular Medicine, 2023 - nature.com
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production,
support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate …

Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W Xie, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2

H Xia, Y Wu, J Zhao, C Cheng, J Lin, Y Yang… - Cell Death & …, 2023 - nature.com
Epithelial cell damage-initiated chronic obstructive pulmonary disease (COPD) is implicated
in regulated cell death (RCD) including ferroptosis triggered by complex gene-environment …

Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases

Y Wang, J Hu, S Wu, JS Fleishman, Y Li, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids

P Yang, J Li, T Zhang, Y Ren, Q Zhang, R Liu… - Cell Death & …, 2023 - nature.com
Ferroptosis is a type of cell death characterized by the accumulation of intracellular iron and
an increase in hazardous lipid peroxides. Ferroptosis and autophagy are closely related …

Malic enzyme 1 as a novel anti‐ferroptotic regulator in hepatic ischemia/reperfusion injury

X Fang, J Zhang, Y Li, Y Song, Y Yu, Z Cai… - Advanced …, 2023 - Wiley Online Library
Ferroptosis has been linked to the pathogenesis of hepatic injury induced by
ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by …

Tactile Sensors: Hydroxyl Decorated Silver Metal–Organic Frameworks for Detecting Cr2O72–, MnO4, Humic Acid, and Fe3+ Ions

B Mohan, S Ma, S Kumar, Y Yang… - ACS Applied Materials & …, 2023 - ACS Publications
Anionic, acidic, and metal ions are common contaminants in water and cause serious
concerns for human and aquatic life. With the goal of rapid detection of analytes, we herein …

Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles alleviates acute liver injury

X Shan, J Li, J Liu, B Feng, T Zhang, Q Liu… - Nature …, 2023 - nature.com
Ferroptosis, a newly characterized form of regulated cell death, is induced by excessive
accumulation of lipid peroxidation catalyzed by intracellular bioactive iron. Increasing …