Organic electronics has made great progress in the past decades, which is inseparable from
the innovative development of organic electronic devices and the diversity of organic …

Chemically fueled autonomous molecular machines are catalysis-driven systems governed
by Brownian information ratchet mechanisms. One fundamental principle behind their …

Pumps and motors are essential components of the world as we know it. From the complex
proteins that sustain our cells, to the mechanical marvels that power industries, much we …

Myosin modulators are a novel class of pharmaceutical agents that are being developed to
treat patients with a range of cardiomyopathies. The therapeutic goal of these drugs is to …

Filopodia are dynamic cell surface protrusions used for cell motility, pathogen infection, and
tissue development. The molecular mechanisms determining how and where filopodia grow …

Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …

The design of compounds that can discriminate between closely related target proteins
remains a central challenge in drug discovery. Specific therapeutics targeting the highly …

Muscle contraction and a range of critical cellular functions rely on force-producing
interactions between myosin motors and actin filaments, powered by turnover of adenosine …

As the prototype of unconventional myosin motor family, myosin Va (MyoVa) transport
cellular cargos along actin filaments in diverse cellular processes. The off-duty MyoVa …

Ethosuximide (ETX) is a common drug in the treatment of absence epilepsy. ETX is known to
act via inhibition of T-type voltage gated Ca2þ channels. Later, it was shown that ETX blocks …