Recent research progress of organic small‐molecule semiconductors with high electron mobilities
J Chen, W Zhang, L Wang, G Yu - Advanced Materials, 2023 - Wiley Online Library
Organic electronics has made great progress in the past decades, which is inseparable from
the innovative development of organic electronic devices and the diversity of organic …
the innovative development of organic electronic devices and the diversity of organic …
Using catalysis to drive chemistry away from equilibrium: relating kinetic asymmetry, power strokes, and the Curtin–Hammett principle in Brownian ratchets
Chemically fueled autonomous molecular machines are catalysis-driven systems governed
by Brownian information ratchet mechanisms. One fundamental principle behind their …
by Brownian information ratchet mechanisms. One fundamental principle behind their …
Molecular pumps and motors
Pumps and motors are essential components of the world as we know it. From the complex
proteins that sustain our cells, to the mechanical marvels that power industries, much we …
proteins that sustain our cells, to the mechanical marvels that power industries, much we …
[HTML][HTML] Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure
SM Day, JC Tardiff, EM Ostap - The Journal of clinical …, 2022 - Am Soc Clin Investig
Myosin modulators are a novel class of pharmaceutical agents that are being developed to
treat patients with a range of cardiomyopathies. The therapeutic goal of these drugs is to …
treat patients with a range of cardiomyopathies. The therapeutic goal of these drugs is to …
[HTML][HTML] Filopodia in vitro and in vivo
TCA Blake, JL Gallop - Annual Review of Cell and …, 2023 - annualreviews.org
Filopodia are dynamic cell surface protrusions used for cell motility, pathogen infection, and
tissue development. The molecular mechanisms determining how and where filopodia grow …
tissue development. The molecular mechanisms determining how and where filopodia grow …
[HTML][HTML] Cardiac myosin contraction and mechanotransduction in health and disease
SK Barrick, MJ Greenberg - Journal of Biological Chemistry, 2021 - ASBMB
Cardiac myosin is the molecular motor that powers heart contraction by converting chemical
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …
energy from ATP hydrolysis into mechanical force. The power output of the heart is tightly …
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
The design of compounds that can discriminate between closely related target proteins
remains a central challenge in drug discovery. Specific therapeutics targeting the highly …
remains a central challenge in drug discovery. Specific therapeutics targeting the highly …
[HTML][HTML] Multistep orthophosphate release tunes actomyosin energy transduction
L Moretto, M Ušaj, O Matusovsky, DE Rassier… - Nature …, 2022 - nature.com
Muscle contraction and a range of critical cellular functions rely on force-producing
interactions between myosin motors and actin filaments, powered by turnover of adenosine …
interactions between myosin motors and actin filaments, powered by turnover of adenosine …
Autoinhibition and activation mechanisms revealed by the triangular-shaped structure of myosin Va
As the prototype of unconventional myosin motor family, myosin Va (MyoVa) transport
cellular cargos along actin filaments in diverse cellular processes. The off-duty MyoVa …
cellular cargos along actin filaments in diverse cellular processes. The off-duty MyoVa …
Cryo-EM structure of the folded-back state of human β-cardiac myosin
A Grinzato, D Auguin, C Kikuti, N Nandwani… - Biophysical …, 2023 - cell.com
Ethosuximide (ETX) is a common drug in the treatment of absence epilepsy. ETX is known to
act via inhibition of T-type voltage gated Ca2þ channels. Later, it was shown that ETX blocks …
act via inhibition of T-type voltage gated Ca2þ channels. Later, it was shown that ETX blocks …