Protein N-terminal acetylation: structural basis, mechanism, versatility, and regulation
S Deng, R Marmorstein - Trends in biochemical sciences, 2021 - cell.com
N-terminal acetylation (NTA) is one of the most widespread protein modifications, which
occurs on most eukaryotic proteins, but is significantly less common on bacterial and …
occurs on most eukaryotic proteins, but is significantly less common on bacterial and …
N-terminal modifications, the associated processing machinery, and their evolution in plastid-containing organisms
T Meinnel, C Giglione - Journal of Experimental Botany, 2022 - academic.oup.com
The N-terminus is a frequent site of protein modifications. Referring primarily to knowledge
gained from land plants, here we review the modifications that change protein N-terminal …
gained from land plants, here we review the modifications that change protein N-terminal …
Cotranslational N-degron masking by acetylation promotes proteome stability in plants
E Linster, FL Forero Ruiz, P Miklankova… - Nature …, 2022 - nature.com
N-terminal protein acetylation (NTA) is a prevalent protein modification essential for viability
in animals and plants. The dominant executor of NTA is the ribosome tethered Nα …
in animals and plants. The dominant executor of NTA is the ribosome tethered Nα …
Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction
CM François, T Pihl, M Dunoyer de Segonzac… - Nature …, 2023 - nature.com
The molecular mechanisms connecting cellular metabolism with differentiation remain
poorly understood. Here, we find that metabolic signals contribute to stem cell differentiation …
poorly understood. Here, we find that metabolic signals contribute to stem cell differentiation …
Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation
WV Bienvenut, A Brünje, JB Boyer… - Molecular Systems …, 2020 - embopress.org
Protein acetylation is a highly frequent protein modification. However, comparatively little is
known about its enzymatic machinery. N‐α‐acetylation (NTA) and ε‐lysine acetylation (KA) …
known about its enzymatic machinery. N‐α‐acetylation (NTA) and ε‐lysine acetylation (KA) …
The dynamic architecture of Map1-and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains
AG Knorr, T Mackens-Kiani, J Musial… - PLoS …, 2023 - journals.plos.org
Cotranslational modification of the nascent polypeptide chain is one of the first events during
the birth of a new protein. In eukaryotes, methionine aminopeptidases (MetAPs) cleave off …
the birth of a new protein. In eukaryotes, methionine aminopeptidases (MetAPs) cleave off …
HYPK promotes the activity of the Nα-acetyltransferase A complex to determine proteostasis of nonAc-X2/N-degron–containing proteins
P Miklánková, E Linster, JB Boyer, J Weidenhausen… - Science …, 2022 - science.org
In humans, the Huntingtin yeast partner K (HYPK) binds to the ribosome-associated N α-
acetyltransferase A (NatA) complex that acetylates~ 40% of the proteome in humans and …
acetyltransferase A (NatA) complex that acetylates~ 40% of the proteome in humans and …
The lowdown on breakdown: Open questions in plant proteolysis
Proteolysis, including post-translational proteolytic processing as well as protein
degradation and amino acid recycling, is an essential component of the growth and …
degradation and amino acid recycling, is an essential component of the growth and …
Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases
RD Etherington, M Bailey, JB Boyer… - Plant …, 2023 - academic.oup.com
Abstract The acetylation-dependent (Ac/) N-degron pathway degrades proteins through
recognition of their acetylated N-termini (Nt) by E3 ligases called Ac/N-recognins. To date …
recognition of their acetylated N-termini (Nt) by E3 ligases called Ac/N-recognins. To date …
Evolution-driven versatility of N terminal acetylation in photoautotrophs
C Giglione, T Meinnel - Trends in plant science, 2021 - cell.com
N terminal protein α-acetylation (NTA) is a pervasive protein modification that has recently
attracted renewed interest. Early studies on NTA were mostly conducted in yeast and …
attracted renewed interest. Early studies on NTA were mostly conducted in yeast and …