The AMPK pathway in fatty liver disease

C Fang, J Pan, N Qu, Y Lei, J Han, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …

Adiponectin and cognitive decline

MR Rizzo, R Fasano, G Paolisso - International journal of molecular …, 2020 - mdpi.com
Adiponectin (ADPN) is a plasma protein secreted by adipose tissue showing pleiotropic
effects with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Initially, it was …

Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice

E Munukka, A Rintala, R Toivonen, M Nylund… - The ISME …, 2017 - academic.oup.com
Faecalibacterium prausnitzii is considered as one of the most important bacterial indicators
of a healthy gut. We studied the effects of oral F. prausnitzii treatment on high-fat fed mice …

Metabolic regulation of adipose tissue macrophage function in obesity and diabetes

M Appari, KM Channon, E McNeill - Antioxidants & Redox Signaling, 2018 - liebertpub.com
Significance: Obesity and diabetes are associated with chronic activation of inflammatory
pathways that are important mechanistic links between insulin resistance (IR), type 2 …

Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in …

RCL Ng, OY Cheng, M Jian, JSC Kwan… - Molecular …, 2016 - Springer
Background Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus
(T2DM) and these patients have doubled risk of Alzheimer's disease (AD). Increasing …

Adiponectin-resistance in obesity

A Engin - Obesity and lipotoxicity, 2017 - Springer
The decrease in adiponectin levels are negatively correlated with chronic subclinical
inflammation markers in obesity. The hypertrophic adipocytes cause obesity-linked insulin …

Adiponectin system (rescue hormone): The missing link between metabolic and cardiovascular diseases

MA Aljafary, EA Al-Suhaimi - Pharmaceutics, 2022 - mdpi.com
The adipose tissue, regardless of its role in generating and storing energy, acts as a key
player as an endocrine tissue, producing a wide scale of cytokines/hormones called …

Selenium and metabolic disorders: an emphasis on type 2 diabetes risk

AN Ogawa-Wong, MJ Berry, LA Seale - Nutrients, 2016 - mdpi.com
Selenium (Se) is a micronutrient that maintains biological functions through the action of Se
containing proteins known as selenoproteins. Due to the known antioxidant effects of Se …

Visceral adiposity syndrome

HF Lopes, ML Corrêa-Giannella… - Diabetology & metabolic …, 2016 - Springer
The association of anthropometric (waist circumference) and hemodynamic (blood pressure)
changes with abnormalities in glucose and lipid metabolism has been motivation for a lot of …

Phloretin and phloridzin improve insulin sensitivity and enhance glucose uptake by subverting PPARγ/Cdk5 interaction in differentiated adipocytes

S Kumar, K Sinha, R Sharma, R Purohit… - Experimental cell …, 2019 - Elsevier
Activators of peroxisome proliferator-activated receptor-γ (PPARγ agonists) are
therapeutically promising candidates against insulin resistance and hyperglycemia …