Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

Primary cilia project in a single copy from the surface of most vertebrate cell types; they
detect and transmit extracellular cues to regulate diverse cellular processes during …

Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The
dysfunction of cilia causes diseases known as ciliopathies. The number of reported …

The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

Signaling receptors dynamically exit cilia upon activation of signaling pathways such as
Hedgehog. Here, we find that when activated G protein-coupled receptors (GPCRs) fail to …

Primary cilia are hair-like organelles and play crucial roles in vertebrate development,
organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory …

Dominantly inherited isolated polycystic liver disease (PCLD) consists of liver cysts that are
radiologically and pathologically identical to those seen in autosomal dominant polycystic …

During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases,
diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs …

Cellular signal transmission requires the dynamic formation of spatiotemporally controlled
molecular interactions. At the cell surface information is received by receptor complexes and …

Primary cilia protrude from most vertebrate cell bodies and act as specialized 'signalling
antennae'that can substantially lengthen or retract in minutes to hours in response to specific …